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Information on EC 1.1.4.1 - vitamin-K-epoxide reductase (warfarin-sensitive)

for references in articles please use BRENDA:EC1.1.4.1

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transferred to EC 1.17.4.4
IUBMB Comments

In the reverse reaction, vitamin K 2,3-epoxide is reduced to vitamin K and possibly to vitamin K hydroquinone by 1,4-dithiothreitol, which is oxidized to a disulfide; some other dithiols and 4-butanethiol can also act. Inhibited strongly by warfarin [cf. EC 1.1.4.2 vitamin-K-epoxide reductase (warfarin-insensitive)].

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