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Information on EC 1.1.3.45 - aclacinomycin-N oxidase

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.3 With oxygen as acceptor
                1.1.3.45 aclacinomycin-N oxidase
IUBMB Comments
A flavoprotein (FAD). This bifunctional enzyme is a secreted flavin-dependent enzyme that is involved in the modification of the terminal sugar residues in the biosynthesis of aclacinomycins. The enzyme utilizes the same active site to catalyse the oxidation of the rhodinose moiety of aclacinomycin N to the cinerulose A moiety of aclacinomycin A and the oxidation of the latter to the L-aculose moiety of aclacinomycin Y (cf. EC 1.3.3.14, aclacinomycin A oxidase).
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Word Map
  • 1.1.3.45
  • sirtuins
  • deacetylation
  • nad+-dependent
  • nicotinamide
  • hyperacetylation
  • mnsod
  • caloric
  • sirt3-dependent
  • longevity
  • sirt3-mediated
  • sirts
  • sirt1-7
  • foxo3a
  • acetylome
  • honokiol
The enzyme appears in viruses and cellular organisms
Synonyms
aknox, aclacinomycin oxidoreductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
aclacinomycin N + O2 = aclacinomycin A + H2O2
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