Information on EC 1.1.3.39 - nucleoside oxidase (H2O2-forming)

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EC Tree 1 Oxidoreductases 1.1 Acting on the CH-OH group of donors 1.1.3 With oxygen as acceptor 1.1.3.39 nucleoside oxidase (H2O2-forming)

IUBMB Comments

A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2′-deoxyribonucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5′-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water.

The expected taxonomic range for this enzyme is: Elizabethkingia meningoseptica

Reaction Schemes

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2

2 entries

adenosine + O2 = 5'-dehydroadenosine + H2O2

adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2

A heme-containing flavoprotein, FAD. Other purine and pyrimidine nucleosides, as well as 2'-deoxynucleosides and arabinosides, are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps: 1. adenosine and O2: 5'-dehydroadenosine and H2O2 2. 5'dehydroadenosine and O2: 9-riburonosyladenine + H2O2 with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

oxidation

redox reaction

reduction

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SYSTEMATIC NAME

IUBMB Comments

nucleoside:oxygen 5'-oxidoreductase (H2O2-forming)

A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water.

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CAS REGISTRY NUMBER

COMMENTARY

82599-71-1

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

1,N6-ethenoadenosine + O2

9-riburonosyl-1,N6-ethenoadenine + H2O2