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2-deoxy-20-hydroxyecdysone + O2
3-dehydro-2-deoxy-20-hydroxyecdysone + H2O2
2-deoxyecdysone + O2
3-dehydro-2-deoxyecdysone + H2O2
20-hydroxyecdysone + O2
3-dehydro-20-hydroxyecdysone + H2O2
5,20-dihydroxyecdysone + O2
3-dehydro-5,20-dihydroxyecdysone + H2O2
-
-
-
-
?
cyasterone + O2
3-dehydrocyasterone + H2O2
ecdysone + O2
3-dehydroecdysone + H2O2
ecdysone + oxidized 2,6-dichloroindophenol
3-dehydroecdysone + reduced 2,6-dichloroindophenol
ecdysteroids + O2
3-dehydroecdysteroids + H2O2
inokosterone + O2
3-dehydroinokosterone + H2O2
makisterone + O2
3-dehydromakisterone + H2O2
2-deoxy-20-hydroxyecdysone + O2
3-dehydro-2-deoxy-20-hydroxyecdysone + H2O2
-
-
-
-
?
2-deoxy-20-hydroxyecdysone + O2
3-dehydro-2-deoxy-20-hydroxyecdysone + H2O2
-
-
-
?
2-deoxyecdysone + O2
3-dehydro-2-deoxyecdysone + H2O2
-
-
-
-
?
2-deoxyecdysone + O2
3-dehydro-2-deoxyecdysone + H2O2
-
-
-
?
20-hydroxyecdysone + O2
3-dehydro-20-hydroxyecdysone + H2O2
-
-
-
-
?
20-hydroxyecdysone + O2
3-dehydro-20-hydroxyecdysone + H2O2
-
probably part of the catabolic system that inactivates the molting hormones
-
-
?
20-hydroxyecdysone + O2
3-dehydro-20-hydroxyecdysone + H2O2
-
-
-
?
20-hydroxyecdysone + O2
3-dehydro-20-hydroxyecdysone + H2O2
-
first step in reaction sequence for the conversion of ecdysone and 20-hydroxyecdysone to their 3(alpha)-epimers
-
-
?
cyasterone + O2
3-dehydrocyasterone + H2O2
-
-
-
-
?
cyasterone + O2
3-dehydrocyasterone + H2O2
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
i.e. 2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one
i.e. 2beta,14alpha,22,25-tetrahydroxy-5beta-cholest-7-en-3,6-dione
ir
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
inactivation of ecdysone
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
-
ir
ecdysone + O2
3-dehydroecdysone + H2O2
-
artificial electron acceptors in vitro in ascending order: ferricyanide, methylene blue, 2,6-dichloroindophenol, 5-methazine methyl sulfate
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
artificial electron acceptors in vitro in ascending order: ferricyanide, methylene blue, 2,6-dichloroindophenol, 5-methazine methyl sulfate
i.e. 2beta,14alpha,22,25-tetrahydroxy-5beta-cholest-7-en-3,6-dione
ir
ecdysone + O2
3-dehydroecdysone + H2O2
-
2,6-dichloroindophenol can act as acceptor
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
2,6-dichloroindophenol can act as acceptor
i.e. 2beta,14alpha,22,25-tetrahydroxy-5beta-cholest-7-en-3,6-dione
ir
ecdysone + O2
3-dehydroecdysone + H2O2
-
FAD, NAD+, NADP+, and FMN can serve as hydrogen acceptors
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
i.e. 2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one
i.e. 2beta,14alpha,22,25-tetrahydroxy-5beta-cholest-7-en-3,6-dione
ir
ecdysone + O2
3-dehydroecdysone + H2O2
-
probably part of the catabolic system that inactivates the molting hormones
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
i.e. 2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one
i.e. 2beta,14alpha,22,25-tetrahydroxy-5beta-cholest-7-en-3,6-dione
ir
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
i.e. 2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one
i.e. 2beta,14alpha,22,25-tetrahydroxy-5beta-cholest-7-en-3,6-dione
ir
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
i.e. 2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one
i.e. 2beta,14alpha,22,25-tetrahydroxy-5beta-cholest-7-en-3,6-dione
ir
ecdysone + O2
3-dehydroecdysone + H2O2
-
i.e. 2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one
i.e. 2beta,14alpha,22,25-tetrahydroxy-5beta-cholest-7-en-3,6-dione
ir
ecdysone + O2
3-dehydroecdysone + H2O2
-
i.e. 2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one
i.e. 2beta,14alpha,22,25-tetrahydroxy-5beta-cholest-7-en-3,6-dione
ir
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
first step in reaction sequence for the conversion of ecdysone and 20-hydroxyecdysone to their 3(alpha)-epimers
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
-
?
ecdysone + O2
3-dehydroecdysone + H2O2
-
i.e. 2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one
i.e. 2beta,14alpha,22,25-tetrahydroxy-5beta-cholest-7-en-3,6-dione
ir
ecdysone + oxidized 2,6-dichloroindophenol
3-dehydroecdysone + reduced 2,6-dichloroindophenol
-
-
-
-
r
ecdysone + oxidized 2,6-dichloroindophenol
3-dehydroecdysone + reduced 2,6-dichloroindophenol
-
163% activity compared to O2
-
-
r
ecdysteroids + O2
3-dehydroecdysteroids + H2O2
-
-
-
?
ecdysteroids + O2
3-dehydroecdysteroids + H2O2
-
structural requirements: alpha,beta-unsaturated keto function at C-6 and several hydroxyl functions including the hydroxyls at C-3 and at C-22
-
?
ecdysteroids + O2
3-dehydroecdysteroids + H2O2
-
-
-
?
inokosterone + O2
3-dehydroinokosterone + H2O2
-
-
-
-
?
inokosterone + O2
3-dehydroinokosterone + H2O2
-
-
-
?
makisterone + O2
3-dehydromakisterone + H2O2
-
-
-
-
?
makisterone + O2
3-dehydromakisterone + H2O2
-
-
-
?
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Weinrich, G.F.; Thompson, M.J.; Svoboda, J.A.
Ecdysone oxidase and 3-oxoecdysteroid reductases in Manduca sexta midgut: kinetic parameters
Arch. Insect Biochem. Physiol.
12
201-218
1989
Manduca sexta
-
brenda
Milner, N.P.; Rees, H.H.
Involvement of 3-dehydroecdysone in the 3-epimerization of ecdysone
Biochem. J.
231
369-374
1985
Spodoptera littoralis
brenda
Koolman, J.
Ecdysone oxidase
Methods Enzymol.
111
419-429
1985
Aeshna cyanea, Calliphora vicina, Choristoneura fumiferana, Drosophila hydei, Drosophila melanogaster, Gryllus bimaculatus, Locusta migratoria, Tenebrio molitor
-
brenda
Blais, C.; Lafont, R.
Ecdysteroid metabolism by soluble enzymes from an insect. Metabolic relationships between 3beta-hydroxy-, 3alpha-hydroxy- and 3-oxoecdysteroids
Hoppe-Seyler's Z. Physiol. Chem.
365
809-817
1984
Pieris brassicae
brenda
Koolman, J.
Ecdysone oxidase in insects
Hoppe-Seyler's Z. Physiol. Chem.
359
1315-1321
1978
Calliphora vicina, Daphnis nerii, Drosophila melanogaster, Periplaneta americana
brenda
Koolman, J.; Karlson, P.
Ecdysone oxidase: reaction and specificity
Eur. J. Biochem.
89
453-460
1978
Calliphora vicina
brenda
Koolman, J.; Karlson, P.
Ecdysone Oxidase, an enzyme from the blowfly Calliphora erythrocephala (Meigen)
Hoppe-Seyler's Z. Physiol. Chem.
356
1131-1138
1975
Calliphora vicina
brenda
Chen, J.H.; Powls, R.; Rees, H.H.; Wilkinson, M.C.
Purification of ecdysone oxidase and 3-dehydroecdysone 3-alpha-reductase from the cotton leafworm, Spodoptera littoralis
Insect Biochem. Mol. Biol.
29
899-908
1999
Spodoptera littoralis
-
brenda
Takeuchi, H.; Chen, J.H.; O'Reilly, D.R.; Turner, P.C.; Rees, H.H.
Regulation of ecdysteroid signaling: cloning and characterization of ecdysone oxidase. A novel steroid oxidase from the cotton leafworm, Spodoptera littoralis
J. Biol. Chem.
276
26819-26828
2001
Spodoptera littoralis (Q95NZ0), Spodoptera littoralis
brenda
Weirich, G.F.; Feldlaufer, M.F.; Svoboda, J.A.
Ecdysone oxidase and 3-oxoecdysteroid reductases in Manduca sexta: developmental changes and tissue distribution
Arch. Insect Biochem. Physiol.
23
199-211
1993
Manduca sexta
-
brenda
Webb, T.J.; Powls, R.; Rees, H.H.
Characterization, fractionation and kinetic properties of the enzymes of ecdysteroid 3-epimerization and phosphorylation isolated from the midgut cytosol of the cotton leafworm, Spodoptera littoralis
Insect Biochem. Mol. Biol.
26
809-816
1996
Spodoptera littoralis
-
brenda
Takeuchi, H.; Rigden, D.J.; Ebrahimi, B.; Turner, P.C.; Rees, H.H.
Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration
Biochem. J.
389
637-645
2005
Drosophila melanogaster
brenda
Sun, W.; Shen, Y.H.; Qi, D.W.; Xiang, Z.H.; Zhang, Z.
Molecular cloning and characterization of ecdysone oxidase and 3-dehydroecdysone-3beta-reductase involved in the ecdysone inactivation pathway of silkworm, Bombyx mori
Int. J. Biol. Sci.
8
125-138
2012
Bombyx mori (H6AGY0), Bombyx mori
brenda
Sun, W.; Wang, C.F.; Zhang, Z.
Transcription factor E74A affects the ecdysone titer by regulating the expression of the EO gene in the silkworm, Bomby mori
Biochim. Biophys. Acta
1861
551-558
2017
Bombyx mori
brenda
Sun, W.; Shen, Y.H.; Han, M.J.; Cao, Y.F.; Zhang, Z.
An adaptive transposable element insertion in the regulatory region of the EO gene in the domesticated silkworm, Bombyx mori
Mol. Biol. Evol.
31
3302-3313
2014
Bombyx mori (H6AGY0), Bombyx mori
brenda
Li, Z.; You, L.; Zeng, B.; Ling, L.; Xu, J.; Chen, X.; Zhang, Z.; Palli, S.R.; Huang, Y.; Tan, A.
Ectopic expression of ecdysone oxidase impairs tissue degeneration in Bombyx mori
Proc. Biol. Sci.
282
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2015
Bombyx mori
brenda
Ojha, S.; Tapadia, M.
Transcriptome profiling identifies multistep regulation through E93, Forkhead and Ecdysone oxidase in survival of malpighian tubules during metamorphosis in Drosophila
Int. J. Dev. Biol.
64
321-331
2020
Drosophila melanogaster (Q9VY01)
brenda
Yamamoto, K.; Nagaoka, S.
Identification and localization of a novel ecdysone oxidase in the silkworm, Bombyx mori
J. Insect Biotechnol. Sericol.
86
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2017
Bombyx mori
-
brenda