Any feedback?
Information on EC 1.1.1.81 - hydroxypyruvate reductase
for references in articles please use BRENDA:EC1.1.1.81Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.1.1.81 hydroxypyruvate reductaseSpecify your search results
Word Map
- 1.1.1.81
- peroxisomal
-
photorespiration
-
photorespiratory
- microbodies
- glyoxysomes
- hyphomicrobium
-
pumpkin
-
hexulose
- extorquens
- methylovorum
- biotechnology
- synthesis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
hydroxypyruvate reductase, nadh-hpr, athpr1, nadph-dependent hydroxypyruvate reductase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
At1g12550
beta-hydroxypyruvate reductase
-
-
-
-
D-glycerate dehydrogenase
-
-
-
-
glyoxylate reductase/hydroxypyruvate reductase
glyoxylate/hydroxypyruvate reductase
glyoxylate/hydroxypyruvate reductase A
GRHPR
HPR
HPR1
HPR2
HPR3
HRP
hydroxypyruvate reductase
LCv4_3219
MCA1407
NAD(P)H-dependent hydroxypyruvate reductase
NADH:hydroxypyruvate reductase
-
-
-
-
NADPH-dependent hydroxypyruvate reductase
additional information
GRHPR
bifunctional enzyme with glyoxylate reductase and hydroxypyruvate reductase activities
additional information
-
the enzyme shows bifunctionality also performing the reaction of hydroxypyruvate reductase, EC 1.1.1.81
additional information
-
the enzyme shows bifunctionality also performing the reaction of hydroxypyruvate reductase, EC 1.1.1.81
additional information
-
hydroxypyruvate reductase (EC 1.1.1.81) activity is found for the same protein showing NADH- and NADPH-dependent glyoxylate reductase (EC 1.1.1.26 or 1.1.1.79) activity, closely related to D-glycerate dehydrogense (EC 1.1.1.29)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H + H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
D-glycerate:NADP+ 2-oxidoreductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9059-44-3
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,3-butandione + NAD(P)H
butan-2-ol-3-one + NAD(P)+
-
33 mM, 12% of activity with hydroxypyruvate
-
?
2-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
?
acetoin + NAD(P)H + H+
2,3-butanediol + NAD(P)+
-
33 mM, 14% of activity with hydroxypyruvate
-
?
D-glycerate + NADP+
hydroxypyruvate + NADPH + H+
-
-
-
r
hydroxypyruvate + NAD(P)H + H+
D-glycerate + NAD(P)+
-
-
-
?
oxaloacetate + NAD(P)H
malate + NAD(P)+
-
33 mM, 32% of activity with hydroxypyruvate
-
?
phenylpyruvate + NADPH + H+
D-phenyllactate + NADP+
-
-
-
?
3-hydroxypyruvate + NADH + H+
D-glycerate + NAD+
-
-
-
ir
3-hydroxypyruvate + NADH + H+
D-glycerate + NAD+
-
-
-
-
ir
3-hydroxypyruvate + NADH + H+
D-glycerate + NAD+
-
-
-
-
ir
3-hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
-
-
-
ir
3-hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
-
-
-
-
ir
3-hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
-
-
-
-
ir
3-hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
-
-
-
?
4-hydroxyphenylpyruvate + NADPH + H+
3-(4-hydroxyphenyl)lactate + NADP+
-
-
-
?
4-hydroxyphenylpyruvate + NADPH + H+
3-(4-hydroxyphenyl)lactate + NADP+
reaction of EC 1.1.1.237
-
-
?
D-glycerate + NAD+
hydroxypyruvate + NADH + H+
-
-
-
?
glyoxylate + NAD(P)H
glycolate + NAD(P)+
-
the enzyme is involved in removal of the metabolic by-product from liver
-
-
?
glyoxylate + NAD(P)H
glycolate + NAD(P)+
-
cofactor NADH, 15% of activity with hydroxypyruvate, cofactor NADPH, 1.5% of activity with hydroxypyruvate
-
?
glyoxylate + NAD(P)H
glycolate + NAD(P)+
-
33 mM, 15% activity
-
?
glyoxylate + NAD(P)H
glycolate + NAD(P)+
-
activity with hydroxypyruvate and NADPH is 2fold higher than with other pair of reactants
-
ir
glyoxylate + NADH + H+
glycolate + NAD+
97% of the activity with 3-hydroxypyruvate
-
-
ir
glyoxylate + NADH + H+
glycolate + NAD+
97% of the activity with 3-hydroxypyruvate
-
-
ir
glyoxylate + NADH + H+
glycolate + NAD+
-
24% of the activity with 3-hydroxypyruvate
-
-
ir
glyoxylate + NADH + H+
glycolate + NAD+
-
60% of the activity with 3-hydroxypyruvate
-
-
ir
glyoxylate + NADH + H+
glycolate + NAD+
-
60% of the activity with 3-hydroxypyruvate
-
-
ir
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
-
-
?
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
-
-
?
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
-
-
?
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
-
-
?
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
-
-
?
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
-
-
?
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
-
-
?
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
-
-
?
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
cofactor NADPH, 80% of activity with NADH, rate of oxidation reaction: 1.5% of reduction reaction only with cofactor NADH
-
r
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
-
-
?
hydroxypyruvate + NAD(P)H
D-glycerate + NAD(P)+ + H+
-
-
-
?, r
hydroxypyruvate + NADH + H+
D-glycerate + NAD+
-
-
-
?
hydroxypyruvate + NADH + H+
D-glycerate + NAD+
low activity
-
-
?
hydroxypyruvate + NADH + H+
D-glycerate + NAD+
isoform HPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate
-
-
?
hydroxypyruvate + NADH + H+
D-glycerate + NAD+
isoform HPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly
-
-
?
hydroxypyruvate + NADH + H+
D-glycerate + NAD+
isoform HPR3 prefers NADPH over NADH and glyoxylate over hydroxypyvruvate
-
-
?
hydroxypyruvate + NADH + H+
D-glycerate + NAD+
low activity
-
-
?
hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
-
-
-
r
hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
best substrate
-
-
r
hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
isoform HPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate
-
-
?
hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
isoform HPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly
-
-
?
hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
isoform HPR3 prefers NADPH over NADH and glyoxylate over hydroxypyvruvate
-
-
?
hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
-
-
-
?, r
hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
-
-
-
r
hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
-
key enzyme of the serine cycle
-
-
?
hydroxypyruvate + NADPH + H+
D-glycerate + NADP+
-
key enzyme of the serine cycle
-
-
?
phenylpyruvate + NADPH + H+
phenyllactate + NADP+
-
-
-
?
phenylpyruvate + NADPH + H+
phenyllactate + NADP+
-
-
-
?
additional information
?
-
the enzyme GLYR1 has negligible hydroxypyruvate dependent activity with NADPH
-
-
?
additional information
?
-
the enzyme GLYR1 has negligible hydroxypyruvate dependent activity with NADPH
-
-
?
additional information
?
-
the enzyme GLYR1 has negligible hydroxypyruvate dependent activity with NADPH
-
-
?
additional information
?
-
the enzyme GLYR1 has negligible hydroxypyruvate dependent activity with NADPH
-
-
?
additional information
?
-
the enzyme GLYR1 has negligible hydroxypyruvate dependent activity with NADPH
-
-
?
additional information
?
-
HPR3 prefers NADPH over NADH and converts glycerate to hydroxypyruvate, the purified recombinant HPR3 shows similar activity with hydroxypyruvate and glyoxylate
-
-
?
additional information
?
-
HPR3 prefers NADPH over NADH and converts glycerate to hydroxypyruvate, the purified recombinant HPR3 shows similar activity with hydroxypyruvate and glyoxylate
-
-
?
additional information
?
-
HPR3 prefers NADPH over NADH and converts glycerate to hydroxypyruvate, the purified recombinant HPR3 shows similar activity with hydroxypyruvate and glyoxylate
-
-
?
additional information
?
-
HPR3 prefers NADPH over NADH and converts glycerate to hydroxypyruvate, the purified recombinant HPR3 shows similar activity with hydroxypyruvate and glyoxylate
-
-
?
additional information
?
-
HPR3 prefers NADPH over NADH and converts glycerate to hydroxypyruvate, the purified recombinant HPR3 shows similar activity with hydroxypyruvate and glyoxylate
-
-
?
additional information
?
-
the recombinant AtHPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate. Isozyme AtHPR1 also converts glyoxylate to glycolate, albeit with much lower catalytic efficiency than for hydroxypyruvate
-
-
?
additional information
?
-
the recombinant AtHPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate. Isozyme AtHPR1 also converts glyoxylate to glycolate, albeit with much lower catalytic efficiency than for hydroxypyruvate
-
-
?
additional information
?
-
the recombinant AtHPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate. Isozyme AtHPR1 also converts glyoxylate to glycolate, albeit with much lower catalytic efficiency than for hydroxypyruvate
-
-
?
additional information
?
-
the recombinant AtHPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate. Isozyme AtHPR1 also converts glyoxylate to glycolate, albeit with much lower catalytic efficiency than for hydroxypyruvate
-
-
?
additional information
?
-
the recombinant AtHPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate. Isozyme AtHPR1 also converts glyoxylate to glycolate, albeit with much lower catalytic efficiency than for hydroxypyruvate
-
-
?
additional information
?
-
the recombinant AtHPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly
-
-
?
additional information
?
-
the recombinant AtHPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly
-
-
?
additional information
?
-
the recombinant AtHPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly
-
-
?
additional information
?
-
the recombinant AtHPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly
-
-
?
additional information
?
-
the recombinant AtHPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly
-
-
?
additional information
?
-
isoform HPPR2 has both hydroxyphenylpyruvate reductase and hydroxypyruvate reductase activities
-
-
-
additional information
?
-
isoform HPPR2 has both hydroxyphenylpyruvate reductase and hydroxypyruvate reductase activities
-
-
-
additional information
?
-
-
isoform HPPR2 has both hydroxyphenylpyruvate reductase and hydroxypyruvate reductase activities
-
-
-
additional information
?
-
enzyme HPR2 shows relaxed substrate and cofactor specificity, it also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79). Irreversibility of the HPR2 reaction has been reported
-
-
-
additional information
?
-
-
enzyme HPR2 shows relaxed substrate and cofactor specificity, it also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79). Irreversibility of the HPR2 reaction has been reported
-
-
-
additional information
?
-
the enzyme also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79)
-
-
-
additional information
?
-
the enzyme also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79)
-
-
-
additional information
?
-
isoform HPPR2 has both hydroxyphenylpyruvate reductase and hydroxypyruvate reductase activities
-
-
-
additional information
?
-
enzyme HPR2 shows relaxed substrate and cofactor specificity, it also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79). Irreversibility of the HPR2 reaction has been reported
-
-
-
additional information
?
-
the enzyme also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79)
-
-
-
additional information
?
-
the enzyme also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79)
-
-
-
additional information
?
-
-
enzyme deficiency leads to primary hyperoxaluria type 2 with increased urinary oxalate levels, formation of kidney stones, and renal failure
-
-
?
additional information
?
-
-
structural basis of enzyme substrate specificity, active site structure and substrate binding, no activity with pyruvate, overview
-
-
?
additional information
?
-
enzyme catalyzes NAD(P)H-dependent reduction of hydroxypyruvate or glyoxylate, but does not catalyze the reverse reactions of D-glycerate or glycolate oxidation. No substrates: pyruvate, lactate, oxaloacetate, and 2-oxoglutarate
-
-
-
additional information
?
-
enzyme catalyzes NAD(P)H-dependent reduction of hydroxypyruvate or glyoxylate, but does not catalyze the reverse reactions of D-glycerate or glycolate oxidation. No substrates: pyruvate, lactate, oxaloacetate, and 2-oxoglutarate
-
-
-
additional information
?
-
-
enzyme catalyzes NAD(P)H-dependent reduction of hydroxypyruvate or glyoxylate, but does not catalyze the reverse reactions of D-glycerate or glycolate oxidation. No substrates: pyruvate, lactate, oxaloacetate, and 2-oxoglutarate
-
-
-
additional information
?
-
-
enzyme catalyzes NAD(P)H-dependent reduction of hydroxypyruvate or glyoxylate, but does not catalyze the reverse reactions of D-glycerate or glycolate oxidation. No substrates: pyruvate, lactate, oxaloacetate, and 2-oxoglutarate
-
-
-
additional information
?
-
-
enzyme catalyzes NAD(P)H-dependent reduction of hydroxypyruvate or glyoxylate, but does not catalyze the reverse reactions of D-glycerate or glycolate oxidation. No substrates: pyruvate, lactate, oxaloacetate, and 2-oxoglutarate
-
-
-
additional information
?
-
-
the enzyme is transcriptionally regulated by the peroxisome proliferator-activated receptor alpha, PPARalpha, in liver, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.