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Information on EC 1.1.1.65 - pyridoxine 4-dehydrogenase
for references in articles please use BRENDA:EC1.1.1.65
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.65 pyridoxine 4-dehydrogenase
IUBMB Comments
Also oxidizes pyridoxine phosphate.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 1.1.1.65
- pyridoxal
- 5'-phosphate
- pyridoxamine
-
vitamers
- reductases
-
salvage
-
schizosaccharomyces
- aldose
- pombe
-
interconvertible
-
voltage-gated
showSynonyms
pl reductase, pyridoxine dehydrogenase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dehydrogenase, pyridoxol 4-
-
-
-
-
PL reductase
-
-
-
-
PL-red
-
-
-
-
pyridoxin dehydrogenase
-
-
-
-
pyridoxine dehydrogenase
-
-
-
-
pyridoxol dehydrogenase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
pyridoxine + NADP+ = pyridoxal + NADPH + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II, pyridoxal 5'-phosphate salvage I, pyridoxal 5'-phosphate salvage II (plants)
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SYSTEMATIC NAME
IUBMB Comments
pyridoxine:NADP+ 4-oxidoreductase
Also oxidizes pyridoxine phosphate.
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CAS REGISTRY NUMBER
COMMENTARY
9028-64-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-nitrobenzaldehyde + NADPH
2-nitrobenzyl alcohol + NADP+
Substrates: -
Products: -
Products: -
?
pyridoxine phosphate + NADP+
pyridoxal 5'-phosphate + NADPH
-
Substrates: -
Products: -
Products: -
?
pyridoxine + NADP+
pyridoxal + NADPH
-
Substrates: pyridoxine is identical with pyridoxol, equilibrium lies far to the side of pyridoxol
Products: -
Products: -
r
pyridoxine + NADP+
pyridoxal + NADPH
Substrates: -
Products: -
Products: -
r
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
pyridoxine + NADP+
pyridoxal + NADPH
-
Substrates: pyridoxine is identical with pyridoxol, equilibrium lies far to the side of pyridoxol
Products: -
Products: -
r
pyridoxine + NADP+
pyridoxal + NADPH
Substrates: -
Products: -
Products: -
r
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). PLR1_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
333
0
36815
Swiss-Prot
-
PLR2_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
333
0
36844
Swiss-Prot
-
PLR1_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
345
0
38601
Swiss-Prot
-
A0A0L1ITT7_ASPN3
Aspergillus nomiae NRRL (strain ATCC 15546 / NRRL 13137 / CBS 260.88 / M93)
770
0
84413
TrEMBL
-
A0A1L9NN44_ASPTC
Aspergillus tubingensis (strain CBS 134.48)
321
0
35229
TrEMBL
other Location (Reliability: 4)
A0A1L9UQN1_ASPBC
Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946)
321
0
35203
TrEMBL
Mitochondrion (Reliability: 5)
A0A1M3TMU3_ASPLC
Aspergillus luchuensis (strain CBS 106.47)
321
0
35186
TrEMBL
Mitochondrion (Reliability: 1)
A0A2G7FKZ6_9EURO
320
0
34661
TrEMBL
other Location (Reliability: 5)
A0A2I1C9Q6_ASPN1
Aspergillus novofumigatus (strain IBT 16806)
321
0
34974
TrEMBL
other Location (Reliability: 1)
A0A317WAC8_9EURO
321
0
35103
TrEMBL
-
A0A318Z585_ASPNB
Aspergillus neoniger (strain CBS 115656)
321
0
35257
TrEMBL
Secretory Pathway (Reliability: 4)
A0A319AUZ8_ASPVC
Aspergillus vadensis (strain CBS 113365 / IMI 142717 / IBT 24658)
321
0
35186
TrEMBL
-
A0A319ET11_ASPSB
Aspergillus sclerotiicarbonarius (strain CBS 121057 / IBT 28362)
321
0
35100
TrEMBL
other Location (Reliability: 2)
A0A370Q137_ASPPH
321
0
35248
TrEMBL
-
A0A5N6HP32_9EURO
320
0
34794
TrEMBL
other Location (Reliability: 2)
A0A5N7CKD1_PETAA
320
0
34903
TrEMBL
other Location (Reliability: 1)
A0A8G1RA21_9EURO
321
0
35199
TrEMBL
other Location (Reliability: 4)
A0A8H3T1I7_ASPTU
321
0
35171
TrEMBL
other Location (Reliability: 1)
A0AAN5C3L4_ASPOZ
302
0
32745
TrEMBL
other Location (Reliability: 2)
A2QQD9_ASPNC
Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
321
0
35214
TrEMBL
-
B8NIR6_ASPFN
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)
320
0
34645
TrEMBL
-
G3YG81_ASPNA
Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7)
321
0
35214
TrEMBL
-
I8TLC2_ASPO3
Aspergillus oryzae (strain 3.042)
320
0
34645
TrEMBL
other Location (Reliability: 1)
Q2U2M0_ASPOR
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
320
0
34673
TrEMBL
-
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
purified enzyme very unstable but can be stabilized by low concentrations of various detergents such as Tween 40
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Holzer, H.; Schneider, S.
Purification and characterization of a TPN-dependent pyridoxol dehydrogenase from brewers yeast
Biochim. Biophys. Acta
48
71-76
1961
Saccharomyces cerevisiae
brenda
Nakano, M.; Morita, T.; Yamamoto, T.; Sano, H.; Ashiuchi, M.; Masui, R.; Kuramitsu, S.; Toshiharu, Y.
Purification, molecular cloning, and catalytic activity of Schizosaccharomyces pombe pyridoxal reductase
J. Biol. Chem.
274
23185-23190
1999
Schizosaccharomyces pombe (O14295), Schizosaccharomyces pombe
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.65)
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