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Information on EC 1.1.1.51 - 3(or 17)beta-hydroxysteroid dehydrogenase
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EC Tree
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenaseIUBMB Comments
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
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Word Map
- 1.1.1.51
- testosterone
- androgen
-
steroidogenic
- progesterone
- estradiol
- adrenal
-
steroidogenesis
- androstenedione
- estrone
- testicular
- aromatase
- testis
- ovarian
- leydig
- 17beta-hsds
- dehydroepiandrosterone
- pregnenolone
- gonad
- lh
-
granulosa
- gonadotropin
-
alpha-reductase
- dihydrotestosterone
- cyp11a1
-
alpha-hydroxylase
- acth
- p450scc
- dheas
- luteal
- progestin
-
sulfatase
- pseudohermaphroditism
- trilostane
- hsd3b1
- genitalia
- p450arom
-
alpha-dihydrotestosterone
-
beta-diol
- hirsutism
-
alpha-hydroxysteroid
- 17-hydroxyprogesterone
-
lhcgr
-
alpha-hydroxyprogesterone
-
virilization
-
17-ketosteroids
- synthesis
- drug development
-
hcg-stimulated
-
pubarche
- srd5a2
- diagnostics
-
17-hydroxylase
- medicine
- environmental protection
-
adrenarche
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
3 beta-hydroxysteroid dehydrogenase, 17 beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase, hsd17b1, hsd17b3, 3betahsd, 17beta-hsd1, 17beta-hydroxysteroid dehydrogenases, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hsd3, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
17-ketoreductase
-
-
-
-
17beta-HSD
17beta-HSD type 3
17beta-HSD3
17beta-hydroxy steroid dehydrogenase
-
-
-
-
17beta-hydroxysteroid dehydrogenase
17beta-hydroxysteroid dehydrogenase type 3
17beta-hydroxysteroid: NADP 17-oxidoreductase
3,17beta-HSD
3,17beta-hydroxysteroid dehydrogenase
3beta,17beta-hydroxysteroid dehydrogenase
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-
-
-
3beta-HSD
3beta-HSD/isomerase
3beta-hydroxy steroid dehydrogenase
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-
-
-
3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase
3beta-hydroxysteroid dehydrogenase
3beta-hydroxysteroid dehydrogenase/isomerase
3beta-hydroxystroid oxidoreductase
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-
-
-
3beta/17beta-HSD
3beta17betaHSDH
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-
-
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3betaHSD
beta-hydroxy steroid dehydrogenase
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-
-
-
betahsd
dehydrogenase, 17beta-hydroxy steroid
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-
-
-
dehydrogenase, 3beta-hydroxy steroid
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-
-
-
dehydrogenase, beta-hydroxy steroid
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-
-
-
DELTA5-3beta-HSD
DELTA5-3beta-hydroxysteroid dehydrogenase
HSD17B3
steroid 17beta-reductase
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-
-
-
type 2 17beta-HSD
additional information
3beta-hydroxysteroid dehydrogenase
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-
-
-
additional information
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the enzyme is a member of the short-chain dehydrogenase/reductase, SDR, superfamily
additional information
-
the enzyme belongs to the short-chain alcohol dehydrogenase family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
reduction
oxidation
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-
-
-
redox reaction
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-
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reduction
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-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
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CAS REGISTRY NUMBER
COMMENTARY
9015-81-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-1,2,3,4-tetrahydro-1-naphthol + NAD+
3,4-dihydronaphthalen-1(2H)-one + NADH + H+
i.e. R-tetralol
-
-
?
(S)-1,2,3,4-tetrahydro-1-naphthol + NAD+
3,4-dihydronaphthalen-1(2H)-one + NADH + H+
i.e. S-tetralol
-
-
?
(S)-1,2,3,4-tetrahydro-1-naphthol + NADP+
3,4-dihydronaphthalen-1(2H)-one + NADPH + H+
i.e. S-tetralol
-
-
?
(S)-1-indanol + NAD+
2,3-dihydro-1H-inden-1-one + NADH + H+
-
-
-
?
1-acenaphthenol + NAD+
acenaphthylen-1(2H)-one + NADH + H+
-
-
-
?
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH
11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+
17-oxo steroids + NADPH
?
-
maintenance of balance between oxidized and reduced steroids in blood
-
-
?
17alpha-hydroxypregnenolone + NAD(P)+
17alpha-hydroxy-pregn-5-en-3,20-dione + NAD(P)H + H+
-
-
-
-
?
17alpha-hydroxypregnenolone + NAD(P)H + H+
17alpha-hydroxyprogesterone + NAD(P)+
-
-
-
-
?
17beta-hydroxy-5beta-androstane-3-one + NAD(P)H + H+
testosterone + NAD(P)+
-
-
-
?
2-cyclohexen-1-ol + NAD+
2-cyclohexen-1-one + NADH + H+
-
-
-
?
20alpha-dihydroprogesterone + NAD+
4-pregnen-3alpha,20beta-diol + NADH
-
-
-
-
r
20alpha-dihydroprogesterone + NADP+
4-pregnen-3alpha,20beta-diol + NADPH
-
-
-
-
r
3beta-hydroxy-5alpha-androstan-17-one + NADP+
5alpha-androstane-3,17-dione + NADPH
-
-
-
?
4-androsten-17beta-ol-3-one + NAD(P)+
4-androstene-3,17-dione + NAD(P)H + H+
17keto function is reduced. NADP+ is 3-5times less effective than NAD+
-
-
?
4-estrene-17beta-ol-3-one + NADP+
4-estrene-3,17-dione + NADPH
-
-
-
-
r
5-androsten-3beta-ol-17-one + NAD(P)+
5-androstene-3,17-dione + NAD(P)H + H+
NADP+ is 3-5times less effective than NAD+
-
-
?
5-androstenedione + NADPH
5alpha-dihydrotestosterone + NADP+
-
isozyme 17beta-HSD3
-
-
r
5-pregnen-3beta-ol-20-one + NAD(P)+
5-pregnene-3,20-dione + NAD(P)H + H+
NADP+ is 3-5times less effective than NAD+
-
-
?
5alpha-androst-16-en-3-one + NADH
3beta-hydroxy-5alpha-androst-16-ene + NAD+
-
-
-
?
5alpha-androstan-3alpha-ol-17-one + NAD+
5alpha-androstan-3,17-dione + NADH + H+
-
-
-
?
5alpha-androstan-3beta-ol-17-one + NAD+
5alpha-androstan-3,17-dione + NADH + H+
-
-
-
?
5alpha-androstane-3beta,17beta-diol + NADP+
3beta-hydroxy-5alpha-androstan-17-one + NADPH
-
-
-
?
5alpha-dihydrotestosterone + NAD(P)H
5alpha-androstane-3beta,17beta-diol + NADP+
-
-
-
?
5alpha-pregnan-3alpha-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH + H+
-
-
-
?
5alpha-pregnan-3beta-ol-20-one + NAD(P)+
5alpha-pregnan-3,20-dione + NAD(P)H + H+
NADP+ and NADPH are 3-5times less effective than NAD+ and NADH
-
-
r
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH + H+
-
-
-
?
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnane-3,20-dione + NADH + H+
-
-
-
r
5alpha-pregnane-3,20-dione + NADH + H+
5alpha-pregnan-3beta-ol-20-one + NAD+
-
-
-
r
5beta-androstan-17beta-ol-3-one + NAD+
5beta-androstan-3,17-dione + NADH + H+
-
-
-
?
5beta-androstan-3alpha-ol-17-one + NAD+
5beta-androstan-3,17-dione + NADH + H+
-
-
-
?
5beta-pregnan-20alpha-ol-3-one + NAD+
5beta-pregnan-3,20-dione + NADH + H+
-
-
-
?
5beta-pregnan-3,20-dione + NAD(P)H + H+
3beta-hydroxy-5beta-pregnan-20-one + NAD(P)+
NADP+ is 3-5times less effective than NAD+
-
-
?
5beta-pregnan-3,20-dione + NADH
3beta-hydroxy-5beta-pregnan-20-one + NAD+
-
-
-
?
5beta-pregnan-3beta,21-diol-20-one + NADH + H+
? + NAD+
-
-
-
?
5beta-pregnan-3beta-ol-20-one + NAD(P)+
5-pregnan-3,20-dione + NAD(P)H + H+
NADP+ and NADPH are 3-5times less effective than NAD+ and NADH
-
-
r
5beta-pregnan-3beta-ol-20-one + NAD+
5beta-pregnan-3,20-dione + NADH + H+
-
-
-
?
androstenediol + NAD(P)H + H+
testosterone + NAD(P)+
-
reaction catalysed by 3beta-HSD (type 1)
-
-
?
androstenedione + NAD(P)H + H+
testosterone + NAD(P)+
-
reaction catalysed by 17beta-HSD (type 1 and 3)
-
-
?
androsterone + NADPH + H+
androstane-3beta,17beta-diol + NADP+
-
reduction at C17
-
-
?
beta-ionol + NAD+
(3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one + NADH + H+
-
-
-
?
dehydroepiandrosterone + NAD(P)H + H+
androstenediol + NAD(P)+
-
reaction catalysed by 17beta-HSD (type 1 and 3)
-
-
?
dehydroepiandrosterone + NADPH + H+
androst-5-ene-3beta,17beta-diol + NADP+
-
-
-
-
?
dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + NADP+
-
androsterone inactivation
-
-
?
epiandrosterone + NADPH
5-androstane-3beta,17beta-diol + NADP+
-
reduction at C17
-
-
?
epiandrosterone + NADPH
androstane-3beta,17beta-diol + NADP+
reduction at C17
-
-
?
estrogenic estrone + NAD(P)H + H+
17beta-estradiol + NAD(P)+
the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases
-
-
?
estrone + NAD(P)H + H+
estradiol + NAD(P)+
-
reaction catalysed by 17beta-HSD (type 1 and 3)
-
-
?
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH
11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+
i.e. 11beta-hydroxy-androstenedione, reduction at C17
i.e. 11beta-testosterone
-
?
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH
11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+
-
i.e. 11beta-hydroxy-androstenedione, reduction at C17
i.e. 11beta-testosterone
-
?
3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one + NAD(P)+
?
-
-
-
-
?
3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one + NAD(P)+
?
-
-
-
-
?
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
-
isozymes 17beta-HSD3 and 17beta-HSD5
-
-
r
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
-
selective reduction at C17
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstane-3,17-dione + NADPH + H+
-
-
-
-
r
5alpha-dihydrotestosterone + NADP+
5alpha-androstane-3,17-dione + NADPH + H+
-
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstane-3,17-dione + NADPH + H+
-
-
-
?
5beta-pregnan-3,20-dione + NA