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Information on EC 1.1.1.422 - pseudoephedrine dehydrogenase

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EC Tree
IUBMB Comments
The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters. It accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity. In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial. The enzyme exhibits a strict anti-Prelog enantioselectivity. When acting on diketones, it catalyses the reduction of only the keto group closest to the ring, with no further reduction to the diol. cf. EC 1.1.1.423, ephedrine dehydrogenase.
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The expected taxonomic range for this enzyme is: unclassified Arthrobacter
Reaction Schemes
(+)-(1S,2S)-pseudoephedrine
+
=
(S)-2-methylamino-1-phenylpropan-1-one
+
+
Synonyms
pseudoephedrine dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(+)-(1S,2S)-pseudoephedrine + NAD+ = (S)-2-methylamino-1-phenylpropan-1-one + NADH + H+
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