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IUBMB CommentsThe enzyme, characterized from bacteria, is involved in L-threonate catabolism.
The enzyme appears in viruses and cellular organisms
Synonyms
L-threonate dehydrogenase, L-threonic acid dehydrogenase,
ltnD, ThrDH,
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L-threonate dehydrogenase
L-threonic acid dehydrogenase
L-threonate dehydrogenase
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L-threonate dehydrogenase
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L-threonate dehydrogenase
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L-threonate dehydrogenase
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L-threonic acid dehydrogenase
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L-threonic acid dehydrogenase
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L-threonic acid dehydrogenase
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L-threonic acid dehydrogenase
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L-threonic acid dehydrogenase
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L-threonic acid dehydrogenase
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ltnD
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-
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ThrDH
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L-threonate + NAD+ = 2-dehydro-L-erythronate + NADH + H+
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-
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L-threonate:NAD+ 2-oxidoreductase
The enzyme, characterized from bacteria, is involved in L-threonate catabolism.
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D-xylonate + NAD+
? + NADH + H+
L-idonate + NAD+
L-sorbosonic acid + NADH + H+
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
L-threonate + NAD+
3-dehydro-L-erythronate + NADH + H+
L-threonate + NADP+
2-dehydro-L-erythronate + NADPH + H+
D-gluconate + NAD+
?
-
-
-
?
D-gluconate + NAD+
?
-
-
-
?
D-xylonate + NAD+
? + NADH + H+
-
-
-
?
D-xylonate + NAD+
? + NADH + H+
-
-
-
?
L-idonate + NAD+
L-sorbosonic acid + NADH + H+
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-
-
?
L-idonate + NAD+
L-sorbosonic acid + NADH + H+
-
-
-
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
-
-
-
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
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-
-
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
specifically oxidizes L-threonic acid
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-
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
specifically oxidizes L-threonic acid
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-
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
-
-
-
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
-
-
-
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
-
-
-
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
-
-
-
?
L-threonate + NAD+
2-dehydro-L-erythronate + NADH + H+
-
-
-
?
L-threonate + NAD+
3-dehydro-L-erythronate + NADH + H+
-
-
-
?
L-threonate + NAD+
3-dehydro-L-erythronate + NADH + H+
-
-
-
?
L-threonate + NADP+
2-dehydro-L-erythronate + NADPH + H+
-
-
-
?
L-threonate + NADP+
2-dehydro-L-erythronate + NADPH + H+
-
-
-
?
L-threonate + NADP+
2-dehydro-L-erythronate + NADPH + H+
-
-
-
?
L-threonate + NADP+
2-dehydro-L-erythronate + NADPH + H+
-
-
-
?
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L-threonate + NAD+
3-dehydro-L-erythronate + NADH + H+
L-threonate + NAD+
3-dehydro-L-erythronate + NADH + H+
-
-
-
?
L-threonate + NAD+
3-dehydro-L-erythronate + NADH + H+
-
-
-
?
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NAD+
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NAD+
NAD+ is preferred over NADP+
NAD+
NAD+ is preferred over NADP+
NAD+
the enzyme is composed of two NAD-binding domains
NADP+
NAD+ is preferred over NADP+
NADP+
NAD+ is preferred over NADP+
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0.62
D-gluconate
pH 8.0, 25°C
4.45
D-xylonate
pH 8.0, 25°C
1.98
L-Idonate
pH 8.0, 25°C
3.6
L-Idonate
pH 8.0, 25°C
0.13
L-threonate
cosubstrate NAD+, pH 8.0, 25°C
0.3
L-threonate
cosubstrate NADP+, pH 8.0, 25°C
0.35
L-threonate
cosubstrate NAD+, pH 8.0, 25°C
0.97
L-threonate
cosubstrate NADP+, pH 8.0, 25°C
1
L-threonate
pH 8.0, 25°C
1.19
L-threonate
pH 8.0, 25°C
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22.4
D-gluconate
pH 8.0, 25°C
15.2
D-xylonate
pH 8.0, 25°C
16.4
L-Idonate
pH 8.0, 25°C
21.1
L-Idonate
pH 8.0, 25°C
2.2
L-threonate
cosubstrate NADP+, pH 8.0, 25°C
4.2
L-threonate
pH 8.0, 25°C
4.7
L-threonate
cosubstrate NADP+, pH 8.0, 25°C
20
L-threonate
pH 8.0, 25°C
29
L-threonate
cosubstrate NAD+, pH 8.0, 25°C
54
L-threonate
cosubstrate NAD+, pH 8.0, 25°C
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36
D-gluconate
pH 8.0, 25°C
3.4
D-xylonate
pH 8.0, 25°C
5.8
L-Idonate
pH 8.0, 25°C
8.3
L-Idonate
pH 8.0, 25°C
4.1
L-threonate
pH 8.0, 25°C
4.8
L-threonate
cosubstrate NADP+, pH 8.0, 25°C
7.5
L-threonate
cosubstrate NADP+, pH 8.0, 25°C
16.8
L-threonate
pH 8.0, 25°C
85
L-threonate
cosubstrate NAD+, pH 8.0, 25°C
410
L-threonate
cosubstrate NAD+, pH 8.0, 25°C
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SwissProt
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SwissProt
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UniProt
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UniProt
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UniProt
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UniProt
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UniProt
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UniProt
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SwissProt
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UniProt
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SwissProt
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LTND_CUPNH
Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
297
0
30439
Swiss-Prot
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LTND_ECOL6
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
302
0
30706
Swiss-Prot
-
LTND_ECOLI
Escherichia coli (strain K12)
302
1
30751
Swiss-Prot
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LTND_HAEIN
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
301
1
31035
Swiss-Prot
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LTND_PECAS
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
304
1
31629
Swiss-Prot
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A0A5M9I2Z8_PSEPA
301
0
30972
TrEMBL
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A0A853T5A1_9BURK
299
0
30559
TrEMBL
-
A0A6S6ZQZ5_9BURK
314
0
32060
TrEMBL
-
A0A6S7CSI0_9BURK
302
0
31099
TrEMBL
-
A0A2P4RGH8_RALPI
303
0
30892
TrEMBL
-
A0A6S7BY51_9BURK
296
0
30104
TrEMBL
-
A0A6J5GVY8_9BURK
296
0
29994
TrEMBL
-
A0A6J5G0R5_9BURK
296
0
30093
TrEMBL
-
A0A6N8HQ99_9BACI
234
0
25081
TrEMBL
-
A0A6A7SG55_9ZZZZ
307
0
31413
TrEMBL
other Location (Reliability: 4)
A0A5E6WT28_PSEFL
298
0
30585
TrEMBL
-
A0A6M4GS72_9PROT
279
0
28769
TrEMBL
-
A0A1X1P7U4_9BURK
296
0
29967
TrEMBL
-
B1G017_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
296
0
30138
TrEMBL
-
A0A6M8MJJ3_9PSED
301
0
31080
TrEMBL
-
A0A418SHP7_9RHOB
288
1
29936
TrEMBL
-
A0A5E7WLU3_PSEFL
301
0
30866
TrEMBL
-
A0A5E7EXU2_PSEFL
301
0
30942
TrEMBL
-
A0A6I1Z748_9ACTN
297
0
30426
TrEMBL
-
A0A2N7WSP5_9BURK
296
0
30089
TrEMBL
-
A0A6G8NIT3_9BURK
300
0
30682
TrEMBL
-
A0A6S7DLF3_9BURK
301
0
30740
TrEMBL
-
A0A653SXD5_9HYPH
296
0
29941
TrEMBL
-
A0A833V6P8_BURGA
296
0
30158
TrEMBL
-
A0A5S9NQD9_9HYPH
309
0
31336
TrEMBL
-
A0A6S7C8L7_9BURK
302
0
30837
TrEMBL
-
A0A6J5CYF5_9BURK
296
0
30264
TrEMBL
-
A0A6J5EG25_9BURK
296
0
29981
TrEMBL
-
A0A6S7B7C4_9BURK
298
0
30600
TrEMBL
-
A0A6S7CLL4_9BURK
302
0
31213
TrEMBL
-
A0A6J4ZS72_9BURK
296
0
30000
TrEMBL
-
A0A6S7F6I4_9BURK
302
0
31171
TrEMBL
-
A0A6S7D9L9_9BURK
301
0
30623
TrEMBL
-
A0A6J5A2T4_9BURK
302
0
30538
TrEMBL
-
A0A6J5KD25_9BURK
302
0
30600
TrEMBL
-
A0A8H2NTU5_PSEFL
301
0
30977
TrEMBL
-
A0A6J5E6R0_9BURK
296
0
30437
TrEMBL
-
A0A6S6ZCE8_9BURK
302
0
30997
TrEMBL
-
A0A5E6WIN0_PSEFL
301
0
31073
TrEMBL
-
A0A5E7RTS7_PSEFL
301
0
30949
TrEMBL
-
A0A5E6QMH4_PSEFL
301
0
31062
TrEMBL
-
A0A6J4ZLB6_9BURK
302
0
30819
TrEMBL
-
A0A6S6ZE83_9BURK
302
0
30740
TrEMBL
-
A0A6S7AMI3_9BURK
302
0
31013
TrEMBL
-
A0A6H2H8P9_9BURK
296
0
30353
TrEMBL
-
B9J8U1_AGRRK
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
294
0
29972
TrEMBL
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B9JKN9_AGRRK
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
322
0
33254
TrEMBL
-
Q1QSN6_CHRSD
Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)
310
1
32144
TrEMBL
-
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Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars
Proc. Natl. Acad. Sci. USA
113
E4161-E4169
2016
Cupriavidus necator (Q0KBC7), Pectobacterium atrosepticum (Q6CZ26), Pectobacterium atrosepticum ATCC BAA-672 (Q6CZ26), Cupriavidus necator DSM 428 (Q0KBC7)
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Zhang, C.F.; Liu, Y.P.; Wu, X.X.; Zhang, X.S.; Huang, H.
Substrate diversity of L-threonic acid dehydrogenase homologs
Biochemistry (Moscow)
85
463-471
2020
Agrobacterium tumefaciens (B9J8U1), Agrobacterium tumefaciens (B9JKN9), Cupriavidus necator (Q0KBC7), Chromohalobacter salexigens (Q1QSN6), Chromohalobacter salexigens ATCC BAA-138 (Q1QSN6), Agrobacterium tumefaciens ATCC BAA-868 (B9J8U1), Agrobacterium tumefaciens ATCC BAA-868 (B9JKN9), Cupriavidus necator ATCC 17699 (Q0KBC7)
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1.1.1.411 L-threonate 2-dehydrogenase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
