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Information on EC 1.1.1.408 - 4-phospho-D-threonate 3-dehydrogenase
for references in articles please use BRENDA:EC1.1.1.408
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.408 4-phospho-D-threonate 3-dehydrogenase
IUBMB Comments
The enzyme, characterized from bacteria, is involved in a pathway for D-threonate catabolism.
The enzyme appears in viruses and cellular organisms
Reaction Schemes
showSynonyms
duf1537, pdxa2, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
D-threonate 4-phosphate dehydrogenase
DUF1537
pdxA2
D-threonate 4-phosphate dehydrogenase
-
D-threonate 4-phosphate dehydrogenase
-
-
pdxA2
-
-
gene name, ambiguous
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3-dehydro-4-phospho-D-erythronate = glycerone phosphate + CO2
(1b), spontaneous
-
-
-
4-phospho-D-threonate + NAD+ = 3-dehydro-4-phospho-D-erythronate + NADH + H+
(1a)
-
-
-
4-phospho-D-threonate + NAD+ = glycerone phosphate + CO2 + NADH + H+
overall reaction
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
4-phospho-D-threonate:NAD+ 3-oxidoreductase
The enzyme, characterized from bacteria, is involved in a pathway for D-threonate catabolism.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-dehydro-4-phospho-D-erythronate
glycerone phosphate + CO2
Substrates: -
Products: spontaneous reaction
Products: spontaneous reaction
?
3-dehydro-4-phospho-D-erythronate
glycerone phosphate + CO2
Substrates: -
Products: spontaneous reaction
Products: spontaneous reaction
?
3-dehydro-4-phospho-D-erythronate
glycerone phosphate + CO2
Substrates: -
Products: spontaneous reaction
Products: spontaneous reaction
?
3-dehydro-4-phospho-D-erythronate
glycerone phosphate + CO2
Substrates: -
Products: spontaneous reaction
Products: spontaneous reaction
?
4-hydroxy-L-threonine 4-phosphate + NAD+
3-amino-2-oxopropyl phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-hydroxy-L-threonine 4-phosphate + NAD+
3-amino-2-oxopropyl phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-hydroxy-L-threonine 4-phosphate + NAD+
3-amino-2-oxopropyl phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-hydroxy-L-threonine 4-phosphate + NAD+
3-amino-2-oxopropyl phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-phospho-D-erythronate + NAD+
glycerone phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-phospho-D-erythronate + NAD+
glycerone phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-phospho-D-erythronate + NAD+
glycerone phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-phospho-D-erythronate + NAD+
glycerone phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-phospho-D-threonate + NAD+
3-dehydro-4-phospho-D-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
4-phospho-D-threonate + NAD+
3-dehydro-4-phospho-D-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
4-phospho-D-threonate + NAD+
3-dehydro-4-phospho-D-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
4-phospho-D-threonate + NAD+
3-dehydro-4-phospho-D-erythronate + NADH + H+
Substrates: -
Products: -
Products: -
?
4-phospho-D-threonate + NAD+
glycerone phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-phospho-D-threonate + NAD+
glycerone phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-phospho-D-threonate + NAD+
glycerone phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
4-phospho-D-threonate + NAD+
glycerone phosphate + CO2 + NADH + H+
Substrates: -
Products: overall reaction
Products: overall reaction
?
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.19
4-hydroxy-L-threonine 4-phosphate
pH 8.0, 25°C
0.054
4-phospho-D-threonate
pH 8.0, 25°C
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.37
4-hydroxy-L-threonine 4-phosphate
pH 8.0, 25°C
8.9
4-phospho-D-threonate
pH 8.0, 25°C
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1.9
4-hydroxy-L-threonine 4-phosphate
pH 8.0, 25°C
160
4-phospho-D-threonate
pH 8.0, 25°C
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
members of the DUF1537 family are ATP-dependent kinases that participate in catabolic pathways for four-carbon acid sugars. PdxA2 participates in a pathway for the conversion of D-threonate to dihydroxyacetone phosphate and CO2. A strain lacking PdxA2 activity is unable to use D-threonate as a carbon source
physiological function
-
members of the DUF1537 family are ATP-dependent kinases that participate in catabolic pathways for four-carbon acid sugars. PdxA2 participates in a pathway for the conversion of D-threonate to dihydroxyacetone phosphate and CO2. A strain lacking PdxA2 activity is unable to use D-threonate as a carbon source
-
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). PDXA2_BORBR
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
351
0
36432
Swiss-Prot
other Location (Reliability: 2)
PDXA2_CLOBH
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
334
0
36273
Swiss-Prot
-
PDXA2_CLOB1
Clostridium botulinum (strain ATCC 19397 / Type A)
334
0
36273
Swiss-Prot
other Location (Reliability: 2)
PDXA2_CLOBL
Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
334
0
36259
Swiss-Prot
-
PDXA2_CLOBK
Clostridium botulinum (strain Okra / Type B1)
334
0
36259
Swiss-Prot
-
PDXA2_CLOBM
Clostridium botulinum (strain Loch Maree / Type A3)
334
0
36273
Swiss-Prot
Chloroplast (Reliability: 2)
PDXA2_CLOBJ
Clostridium botulinum (strain Kyoto / Type A2)
334
0
36273
Swiss-Prot
-
PDXA2_CLOB6
Clostridium botulinum (strain 657 / Type Ba4)
334
0
36314
Swiss-Prot
-
PDXA2_SALTI
327
0
35042
Swiss-Prot
Secretory Pathway (Reliability: 1)
PDXA2_SALTY
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
327
0
35065
Swiss-Prot
-
PDXA2_CUPNH
Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
333
0
35491
Swiss-Prot
other Location (Reliability: 4)
PDXA2_SYMTH
Symbiobacterium thermophilum (strain DSM 24528 / JCM 14929 / IAM 14863 / T)
335
0
36102
Swiss-Prot
-
PDXA2_PECAS
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
326
0
34952
Swiss-Prot
-
PDXA2_CUTAK
Cutibacterium acnes (strain DSM 16379 / KPA171202)
346
0
36659
Swiss-Prot
-
PDXA2_BRADU
Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
345
0
36065
Swiss-Prot
-
PDXA2_OCEIH
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
332
0
36017
Swiss-Prot
-
PDXA2_FUSNN
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)
332
0
36547
Swiss-Prot
-
PDXA2_HALH5
Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
334
0
36632
Swiss-Prot
-
A0A0L6Z657_9CLOT
340
0
36564
TrEMBL
-
A0A0S6U7V2_CLOBO
334
0
36203
TrEMBL
-
A0A170NPH4_9CLOT
333
0
35837
TrEMBL
other Location (Reliability: 3)
A0A1M4UVS4_9CLOT
343
0
37336
TrEMBL
-
A0A1S8MNW3_CLOSA
334
0
35773
TrEMBL
Secretory Pathway (Reliability: 3)
A0A1T4XVV1_9CLOT
350
0
38646
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2G7HG64_9CLOT
334
0
36273
TrEMBL
other Location (Reliability: 1)
A0A2K2FL57_9CLOT
333
0
36114
TrEMBL
-
A0A2T0ASZ8_9CLOT
321
0
35085
TrEMBL
-
A0A3M0TC50_9CLOT
333
0
35837
TrEMBL
other Location (Reliability: 1)
A0A6B4GUD9_CLOBO
334
0
36345
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6G4CSC4_CLOBO
334
0
36323
TrEMBL
other Location (Reliability: 2)
A0A9D1I6P8_9CLOT
345
0
37357
TrEMBL
-
A0A9D1SR94_9CLOT
309
0
33738
TrEMBL
other Location (Reliability: 1)
A0AAW9J8P0_CLOPF
200
0
22323
TrEMBL
other Location (Reliability: 2)
A0ABC8CTP2_CLOBO
334
0
36315
TrEMBL
Secretory Pathway (Reliability: 2)
A0ABD6S0I0_CLOSG
334
0
36272
TrEMBL
other Location (Reliability: 2)
D8GLS1_CLOLD
Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)
333
0
35856
TrEMBL
other Location (Reliability: 4)
D8GUI8_CLOLD
Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)
331
0
36173
TrEMBL
other Location (Reliability: 4)
M1LX07_9CLOT
331
0
35216
TrEMBL
other Location (Reliability: 2)
R4KFZ8_CLOPA
338
0
36785
TrEMBL
other Location (Reliability: 1)
V7I9A3_9CLOT
346
0
37474
TrEMBL
Secretory Pathway (Reliability: 4)
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars
Proc. Natl. Acad. Sci. USA
113
E4161-E4169
2016
Cupriavidus necator (Q0K4F5), Cupriavidus necator DSM 428 (Q0K4F5), Salmonella enterica subsp. enterica serovar Typhimurium (P58718), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (P58718)
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.408)
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