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IUBMB Comments This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert -butyl methyl ether (MTBE), a widely occurring groundwater contaminant.
Synonyms mpdB ,
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2-M1,2-PD dehydrogenase
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2-M1,2-PD dehydrogenase
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mpdB
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2-methylpropane-1,2-diol + NAD+ = 2-hydroxy-2-methylpropanal + NADH + H+
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MetaCyc
2-methylpropene degradation, methyl tert-butyl ether degradation
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2-methylpropane-1,2-diol:NAD+ 1-oxidoreductase
This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant.
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2-methylpropane-1,2-diol + electron acceptor
2-hydroxy-2-methylpropanal + reduced electron acceptor
2-methylpropane-1,2-diol + NAD+
2-hydroxy-2-methylpropanal + NADH + H+
2-methylpropane-1,2-diol + electron acceptor
2-hydroxy-2-methylpropanal + reduced electron acceptor
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Substrates: -
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2-methylpropane-1,2-diol + electron acceptor
2-hydroxy-2-methylpropanal + reduced electron acceptor
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Substrates: -
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2-methylpropane-1,2-diol + NAD+
2-hydroxy-2-methylpropanal + NADH + H+
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Substrates: -
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2-methylpropane-1,2-diol + NAD+
2-hydroxy-2-methylpropanal + NADH + H+
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Substrates: -
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2-methylpropane-1,2-diol + electron acceptor
2-hydroxy-2-methylpropanal + reduced electron acceptor
2-methylpropane-1,2-diol + NAD+
2-hydroxy-2-methylpropanal + NADH + H+
2-methylpropane-1,2-diol + electron acceptor
2-hydroxy-2-methylpropanal + reduced electron acceptor
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Substrates: -
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2-methylpropane-1,2-diol + electron acceptor
2-hydroxy-2-methylpropanal + reduced electron acceptor
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Substrates: -
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2-methylpropane-1,2-diol + NAD+
2-hydroxy-2-methylpropanal + NADH + H+
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Substrates: -
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2-methylpropane-1,2-diol + NAD+
2-hydroxy-2-methylpropanal + NADH + H+
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Substrates: -
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NAD+
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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MPDB_MYCAO
552
0
60181
Swiss-Prot
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64000
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x * 64000, SDS-PAGE
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x * 64000, SDS-PAGE
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x * 64000, SDS-PAGE
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Kottegoda, S.; Waligora, E.; Hyman, M.
Metabolism of 2-methylpropene (isobutylene) by the aerobic bacterium Mycobacterium sp. strain ELW1
Appl. Environ. Microbiol.
81
1966-1976
2015
Mycobacterium sp., Mycobacterium sp. ELW1
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brenda
Lopes Ferreira, N.; Labbe, D.; Monot, F.; Fayolle-Guichard, F.; Greer, C.W.
Genes involved in the methyl tert-butyl ether (MTBE) metabolic pathway of Mycobacterium austroafricanum IFP 2012
Microbiology
152
1361-1374
2006
Mycolicibacterium austroafricanum, Mycolicibacterium austroafricanum IFP 2012
brenda
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