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BRENDA support

Information on EC 1.1.1.397 - beta-methylindole-3-pyruvate reductase

for references in articles please use BRENDA:EC1.1.1.397

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IUBMB Comments

The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan-tRNA ligase (EC 6.1.1.2).

The expected taxonomic range for this enzyme is: Streptomyces griseus

Synonyms
ind2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+ = (R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links