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IUBMB Comments The enzyme takes part in a D -galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina ). It has equal activity with D - and L -glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.
Synonyms
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L-glyceraldehyde reductase
NADP-dependent glycerol dehydrogenase
gaaD
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gld1
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L-glyceraldehyde reductase
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L-glyceraldehyde reductase
-
-
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NADP-dependent glycerol dehydrogenase
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NADP-dependent glycerol dehydrogenase
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-
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glycerol + NADP+ = D-glyceraldehyde + NADPH + H+
(2)
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-
glycerol + NADP+ = L-glyceraldehyde + NADPH + H+
(1)
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-
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MetaCyc
D-galacturonate degradation IV
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glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.
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D-glyceraldehyde + NADPH + H+
glycerol + NADP+
diacetyl + NADPH + H+
?
Substrates: -
?
dihydroxyacetone + NADPH + H+
?
Substrates: -
?
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
methylglyoxal + NADPH + H+
?
additional information
?
-
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
Substrates: -
?
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
Substrates: -
?
glyoxal + NADPH + H+
?
Substrates: -
?
glyoxal + NADPH + H+
?
Substrates: -
?
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
Substrates: -
?
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
Substrates: the activity with L-glyceraldehyde is only slightly lower compared to D-glyceraldehyde
?
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
Substrates: the activity with L-glyceraldehyde is only slightly lower compared to D-glyceraldehyde
?
methylglyoxal + NADPH + H+
?
Substrates: -
?
methylglyoxal + NADPH + H+
?
Substrates: -
?
additional information
?
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Substrates: no activity with NADH or glycerol. Very much reduced activity with dihydroxyacetone. No activity with C5 or C6 sugars (acetoin, D-ribose, D-xylose, and D-glucose)
?
additional information
?
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Substrates: no activity with NADH or glycerol. Very much reduced activity with dihydroxyacetone. No activity with C5 or C6 sugars (acetoin, D-ribose, D-xylose, and D-glucose)
?
additional information
?
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Substrates: no activity with NADH or glycerol. Very much reduced activity with dihydroxyacetone. No activity with C5 or C6 sugars (acetoin, D-ribose, D-xylose, and D-glucose)
?
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D-glyceraldehyde + NADPH + H+
glycerol + NADP+
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
additional information
?
-
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
Substrates: -
?
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
Substrates: -
?
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
Substrates: -
?
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
Substrates: the activity with L-glyceraldehyde is only slightly lower compared to D-glyceraldehyde
?
L-glyceraldehyde + NADPH + H+
glycerol + NADP+
Substrates: the activity with L-glyceraldehyde is only slightly lower compared to D-glyceraldehyde
?
additional information
?
-
Substrates: no activity with NADH or glycerol. Very much reduced activity with dihydroxyacetone. No activity with C5 or C6 sugars (acetoin, D-ribose, D-xylose, and D-glucose)
?
additional information
?
-
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Substrates: no activity with NADH or glycerol. Very much reduced activity with dihydroxyacetone. No activity with C5 or C6 sugars (acetoin, D-ribose, D-xylose, and D-glucose)
?
additional information
?
-
Substrates: no activity with NADH or glycerol. Very much reduced activity with dihydroxyacetone. No activity with C5 or C6 sugars (acetoin, D-ribose, D-xylose, and D-glucose)
?
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NADPH
specific cofactor
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0.9
D-glyceraldehyde
at pH 7.0 and 30°C
0.9
diacetyl
at pH 7.0 and 30°C
5.8
dihydroxyacetone
at pH 7.0 and 30°C
2.4
Glyoxal
at pH 7.0 and 30°C
0.9
L-glyceraldehyde
at pH 7.0 and 30°C
0.4
methylglyoxal
at pH 7.0 and 30°C
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brenda
synonym Trichoderma reesei
UniProt
brenda
synonym Trichoderma reesei
UniProt
brenda
Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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metabolism
the enzyme is active in pathways for sugar acid catabolism such as D-galacturonate catabolism
metabolism
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the enzyme is active in pathways for sugar acid catabolism such as D-galacturonate catabolism
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36232
x * 36232, calculated from amino acid sequence
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?
x * 36232, calculated from amino acid sequence
?
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x * 36232, calculated from amino acid sequence
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Ni-NTA column chromatography
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expressed in Saccharomyces cerevisiae
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Liepins, J.; Kuorelahti, S.; Penttilae, M.; Richard, P.
Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina
FEBS J.
273
4229-4235
2006
Trichoderma reesei (Q0GYU5), Trichoderma reesei, Trichoderma reesei RUT C-30 (Q0GYU5)
brenda
Martens-Uzunova, E.S.; Schaap, P.J.
An evolutionary conserved D-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation
Fungal Genet. Biol.
45
1449-1457
2008
Aspergillus niger
brenda
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