The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.
The expected taxonomic range for this enzyme is: unclassified Streptomyces
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SYSTEMATIC NAME
IUBMB Comments
aklavinone:NADP+ oxidoreductase
The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.
Substrates: the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin. Aklavinone is the last intermediate common to both aclacinomycin and daunomycin biosynthesis Products: -
Substrates: the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin. Aklavinone is the last intermediate common to both aclacinomycin and daunomycin biosynthesis Products: -
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
extracts of Streptomyces lividans TK24 containing recombinant DauE catalyzes the NADPH-specific conversion of aklaviketone, maggiemycin, and 7-oxodaunomycinone to aklavinone, epsilon-rhodomycinone, and daunomycinone, respectively
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