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IUBMB Comments Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of kanamycin B to kanamycin A.
Synonyms
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kanamycin A + NADP+ = 2'-dehydrokanamycin A + NADPH + H+
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MetaCyc
kanamycin biosynthesis
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kanamycin A:NADP+ oxidoreductase
Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of kanamycin B to kanamycin A.
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2'-dehydrokanamycin A + NADPH + H+
kanamycin A + NADP+
2'-dehydrokanamycin A + NADPH + H+
kanamycin A + NADP+
Substrates: the enzyme is involved in the conversion of kanamycin B to kanamycin A. Kanamycin is a clinically important aminoglycoside antibiotic
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2'-dehydrokanamycin A + NADPH + H+
kanamycin A + NADP+
Substrates: i.e. (1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-a-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
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2'-dehydrokanamycin A + NADPH + H+
kanamycin A + NADP+
Substrates: the enzyme is involved in the conversion of kanamycin B to kanamycin A. Kanamycin is a clinically important aminoglycoside antibiotic
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UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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KANK_STRKN
352
0
37159
Swiss-Prot
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expression in Escherichia coli
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Sucipto, H.; Kudo, F.; Eguchi, T.
The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK
Angew. Chem. Int. Ed. Engl.
51
3428-3431
2012
Streptomyces kanamyceticus (Q2MFU6)
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