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IUBMB Comments Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
Synonyms penF , ptlF , SAV_2933,
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1-deoxy-11beta-hydroxypentalenic acid dehydrogenase
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ptlF
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1-deoxy-11beta-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+
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MetaCyc
neopentalenoketolactone and pentalenate biosynthesis, pentalenolactone biosynthesis
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1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase
Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
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1-deoxy-11beta-hydroxypentalenic acid + NAD+
1-deoxy-11-oxopentalenic acid + NADH + H+
Substrates: -
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NAD+
150fold preference for NAD+ over NADP+
NADP+
150fold preference for NAD+ over NADP+
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0.0065
1-deoxy-11beta-hydroxypentalenic acid
pH 8.0, 22°C
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0.65
1-deoxy-11beta-hydroxypentalenic acid
pH 8.0, 22°C
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11.3
activity increases from pH 9.0 to pH 11.3, and is 12fold higher at pH 11.3 than at pH 8.0
8
and second maximum at pH 11.3
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UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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PENF_STREX
275
0
29203
Swiss-Prot
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PNTF_STRAE
282
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29752
Swiss-Prot
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PTLF_STRAW
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
270
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28161
Swiss-Prot
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30183
x * 30183, MALDI-TOF, recombinant protein including His-tag
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x * 30183, MALDI-TOF, recombinant protein including His-tag
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expression in Escherichia coli
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You, Z.; Omura, S.; Ikeda, H.; Cane, D.E.
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate
Arch. Biochem. Biophys.
459
233-240
2007
Streptomyces avermitilis (Q82IY9)
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