We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Synonyms
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dehydrogenase, prostacyclin
-
-
-
-
NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase
-
-
-
-
NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase
-
-
-
-
PG I2 dehydrogenase
-
-
-
-
prostacyclin dehydrogenase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
random mechanism or ordered mechanism with NADP+ binding first
-
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MetaCyc
C20 prostanoid biosynthesis
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase
Specific for prostaglandin I2.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
4-benzoylpyridine + NADP+
?
-
Substrates: recombinant forms CHCR1, CHCR2
?
4-nitrobenzaldehyde + NADP+
4-nitrobenzoate + NADPH
6-keto-prostaglandin F1alpha + NADP+
6,15-diketoprostaglandin F2alpha + NADPH
-
Substrates: at 1.8% the reaction rate of prostaglandin I2
?
menadione + NADP+
?
-
Substrates: more rapid reaction than with prostacyclin
?
phenanthrene quinone + NADP+
?
-
Substrates: more rapid reaction than with prostacyclin
?
prostaglandin B1 + NADP+
15-ketoprostaglandin B1 + NADPH + H+
-
Substrates: at 8% the reaction rate of prostaglandin I2
?
prostaglandin E2 + NADP+
15-ketoprostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
-
Substrates: -
?
prostaglandin F2alpha + NADP+
15-ketoprostaglandin F2alpha + NADPH + H+
pyridine-4-carboxaldehyde + NADP+
?
-
Substrates: recombinant forms CHCR1, CHCR2
?
additional information
?
-
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
-
Substrates: i.e. prostaglandin I2, prostacyclin
?
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
-
Substrates: i.e. prostaglandin I2, prostacyclin
?
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
-
Substrates: -
?
4-nitrobenzaldehyde + NADP+
4-nitrobenzoate + NADPH
-
Substrates: recombinant forms CHCR1, CHCR2
?
4-nitrobenzaldehyde + NADP+
4-nitrobenzoate + NADPH
-
Substrates: more rapid reaction than with prostacyclin
?
prostaglandin E2 + NADP+
15-ketoprostaglandin E2 + NADPH + H+
-
Substrates: -
?
prostaglandin E2 + NADP+
15-ketoprostaglandin E2 + NADPH + H+
-
Substrates: at 4% the reaction rate of prostaglandin I2
?
prostaglandin F2alpha + NADP+
15-ketoprostaglandin F2alpha + NADPH + H+
-
Substrates: -
?
prostaglandin F2alpha + NADP+
15-ketoprostaglandin F2alpha + NADPH + H+
-
Substrates: at 2.2% the reaction rate of prostaglandin I2
?
additional information
?
-
-
Substrates: comparison of 3 15-hydroxyproastaglandin dehydrogenases with varying amounts of 9-ketoprostaglandin reductase activity
?
additional information
?
-
-
Substrates: enzyme catalyzes reduction of 9-keto group in prostaglandin E2 at less than 1% the rate of prostaglandin I2 oxidation
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
-
Substrates: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
no activity with NAD+
-
additional information
-
not a flavoprotein
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0667
4-nitrobenzaldehyde
-
-
0.0005
Phenanthrene quinone
-
-
0.278 - 0.364
prostaglandin I2
0.00538
NADP+
-
-
0.278
prostaglandin I2
-
-
0.364
prostaglandin I2
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1.217
-
recombinant enzyme, latanoprost + NADP+
2.17
-
recombinant enzyme, acid form of latanoprost + NADP+
24.3
-
recombinant enzyme, prostaglandin F2alpha + NADP+
6.08
-
recombinant enzyme, prostaglandin F2alpha + NAD+
9.8
-
recombinant enzyme, prostaglandin E2 + NADP+
additional information
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
chinese hamster
-
-
brenda
-
-
-
brenda
monkey
-
-
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
-
brenda
additional information
-
tissue distribution of m-RNA
brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
28000
-
2 * 28000, rabbit, SDS-PAGE
31000
-
SDs-PAGE of recombinant enzyme
34000
-
SDS-PAGE of recombinant forms CHCR1, CHCR2 including His-tag
56000
-
SDS-PAGE of amidinated enzyme
additional information
-
relationship to NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
additional information
-
three-dimensional model
additional information
-
three-dimensional model
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimer
-
computer modelling
dimer
-
2 * 28000, rabbit, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
freezing and thawing: repeatedly, slow loss of activity
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
stable for months when frozen
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 forms differing due to posttranslational modification at pos. 238
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 enzyme forms CHCR1, CHCR2
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Krook, M.; Ghosh, D.; Duax, W.; Jrnvall, H.
Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase)
FEBS Lett.
322
139-142
1993
Homo sapiens
brenda
Korff, J.M.; Jarabak, J.
Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney
Methods Enzymol.
86
152-155
1982
Oryctolagus cuniculus
brenda
Korff, J.M.; Jarabak, J.
The purification and characterization of a prostacyclin dehydrogenase from rabbit kidney
J. Biol. Chem.
257
2177-2181
1982
Oryctolagus cuniculus
brenda
Fujimori, K.; Okada, T.; Urade, Y.
Expression of NADP(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase mRNA in Monkey Ocular Tissues and Characterization of Its Recombinant Enzyme
J. Biochem.
131
383-389
2002
Macaca fascicularis
brenda
Terada, T.; Sugihara, Y.; Nakamura, K.; Sato, R.; Sakuma, S.; Fujimoto, Y.; Fujita, T.; Inazu, N.; Maeda, M.
Characterization of multiple Chinese hamster carbonyl reductases
Chem. Biol. Interact.
130-132
847-861
2001
Cricetulus griseus
brenda
Jarabak, J.; Luncsford, A.; Berkowitz, D.
Substrate specificity of three prostaglandin dehydrogenases
Prostaglandins
26
849-868
1983
Homo sapiens
brenda
Krook, M.; Ghosh, D.; Stromberg, R.; Carlquist, M.; Jornvall, H.
Carboxyethyllysine in a protein: Native carbonyl reductase/NADP+-dependent prostaglandin dehydrogenase
Proc. Natl. Acad. Sci. USA
90
502-506
1993
Homo sapiens
brenda
html completed
show
top
