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Synonyms
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3beta,20alpha-hydroxysteroid oxidoreductase
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dehydrogenase, 3beta,20alpha-hydroxy steroid
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progesterone reductase
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5alpha-androstan-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + NADPH + H+
5alpha-androstan-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + NADPH + H+
3beta and 20alpha substrates share the same active site
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5alpha-androstan-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + NADPH + H+
3beta and 20alpha substrates share the same active site
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5alpha-androstan-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + NADPH + H+
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MetaCyc
backdoor pathway of androgen biosynthesis
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3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase
Also acts on 20alpha-hydroxysteroids.
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17beta-hydoxy-5alpha-androstan-3-one + NADPH
5alpha-androstan-3beta,17beta-diol + NADP+
17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstan-3beta,17beta-diol + NADP+
progesterone + NADPH
20alpha-hydroxy-4-pregnen-3-one + NADP+
additional information
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Substrates: enzyme is involved in progesterone biosynthesis
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17beta-hydoxy-5alpha-androstan-3-one + NADPH
5alpha-androstan-3beta,17beta-diol + NADP+
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Substrates: -
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17beta-hydoxy-5alpha-androstan-3-one + NADPH
5alpha-androstan-3beta,17beta-diol + NADP+
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Substrates: -
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17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstan-3beta,17beta-diol + NADP+
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Substrates: -
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17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstan-3beta,17beta-diol + NADP+
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Substrates: -
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progesterone + NADPH
20alpha-hydroxy-4-pregnen-3-one + NADP+
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Substrates: -
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progesterone + NADPH
20alpha-hydroxy-4-pregnen-3-one + NADP+
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Substrates: -
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17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstan-3beta,17beta-diol + NADP+
progesterone + NADPH
20alpha-hydroxy-4-pregnen-3-one + NADP+
additional information
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Substrates: enzyme is involved in progesterone biosynthesis
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17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstan-3beta,17beta-diol + NADP+
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Substrates: -
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17beta-hydroxy-5alpha-androstan-3-one + NADPH
5alpha-androstan-3beta,17beta-diol + NADP+
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Substrates: -
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progesterone + NADPH
20alpha-hydroxy-4-pregnen-3-one + NADP+
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Substrates: -
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progesterone + NADPH
20alpha-hydroxy-4-pregnen-3-one + NADP+
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Substrates: -
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NADP+
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NADPH
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16alpha-(Bromoacetoxy)progesterone
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competitive inhibition of 3beta- and 20alpha-reductase activity, time dependent and simultaneous, complete inactivation, 2-mercaptoethanol protects
17beta-hydroxy-5alpha-androstan-3-one
19-Nortestosterone 17-bromoacetate
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competitive inhibition of 3beta- and 20alpha-reductase activity, time dependent and simultaneous, complete inactivation
5alpha-dihydrotestosterone 17-bromoacetate
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competitive inhibition of 3beta- and 20alpha-reductase activity, time dependent and simultaneous, complete inactivation
17beta-hydroxy-5alpha-androstan-3-one
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inhibition of 20alpha-reductase activity
17beta-hydroxy-5alpha-androstan-3-one
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inhibition of 20alpha-reductase activity
progesterone
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inhibition of 3beta-reductase activity
progesterone
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inhibition of 3beta-reductase activity
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0.074
17beta-hydroxy-5alpha-androstan-3-one
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additional information
additional information
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kinetic studies
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0.0025
NADPH
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20alpha-reductase
0.0094
NADPH
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3beta-reductase
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0.0071
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20alpha-reductase activity
0.0096
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20alpha-reductase activity
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assay at
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brenda
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brenda
female Wistar rats
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brenda
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enzyme activity during stages of pseudo-pregnancy, 20alpha-hydroxysteroid dehydrogenase activity increases from day 1 to day 12, overview
brenda
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fetal
brenda
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fetal
brenda
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20alpha-hydroxysteroid dehydrogenase activity
brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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55000
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SDS-PAGE, gel filtration
36000
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SDS-PAGE
36000
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1 * 36000, SDS-PAGE
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monomer
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1 * 55000, SDS-PAGE
monomer
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1 * 36000, SDS-PAGE
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lyophilization, complete loss of activity
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stable to bromoacetic acid
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stable to ethyl bromoacetate
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-20C, purified enzyme, indefinitely stable
-20C, purified enzyme, indefinitely stable
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-20C, purified enzyme, indefinitely stable
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Sharaf, M.A.; Sweet, F.
Dual activity at an enzyme active site: 3beta,20alpha-hydroxysteroid oxidoreductase from fetal blood
Biochemistry
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4615-4620
1982
Bos taurus
brenda
Chen, Q.; Nancarrow, C.D.; Sweet, F.
Isolation of 3beta,20alpha-hydroxysteroid oxidoreductase from sheep fetal blood
Steroids
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477-496
1987
Ovis aries
brenda
Chen, Q.; Rosik, L.O.; Nancarrow, C.D.; Sweet, F.
Fetal lamb 3beta,20alpha-hydroxysteroid oxidoreductase: dual activity at the same active site examined by affinity labeling with 16alpha-(bromo[2-14C]acetoxy)progesterone
Biochemistry
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8856-8863
1989
Ovis aries
brenda
Chen, Q.; Sweet, F.
Identification of histidine residue in the active site of fetal lamb 3beta,20alpha-hydroxysteroid oxidoreductase
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan
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113-117
1991
Ovis aries
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brenda
Clementi, M.A.; Deis, R.P.; Telleria, C.M.
Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: effect of the deciduoma reaction
Reprod. Biol. Endocrinol.
2
22
2004
Rattus norvegicus
brenda
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