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Information on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)
for references in articles please use BRENDA:EC1.1.1.197
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)
IUBMB Comments
Acts on prostaglandins E2, F2α and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
The enzyme appears in viruses and cellular organisms
- 1.1.1.197
- swine
- dehydrogenases
-
nadp+-dependent
-
15-ketoprostaglandin
-
nadph-linked
- reductases
- valine
- monkey
- medulla
Reaction Schemes
showSynonyms
prostaglandin e 9-ketoreductase, 9-ketoprostaglandin reductase, nadp-dependent 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin dehydrogenase (nadp+), more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
NADP-dependent 15-hydroxyprostaglandin dehydrogenase
-
-
-
-
NADP-linked 15-hydroxyprostglandin dehydrogenase
-
-
-
-
NADP-specific 15-hydroxyprostaglandin dehydrogenase
-
-
-
-
prostaglandin E 9-ketoreductase
type II 15-hydroxyprostaglandin dehydrogenase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2[cf. EC1.1.1.141 (NADP)]. May be identical with EC1.1.1.189 prostaglandin-E2 9-reductase
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
di-homo-gamma-linolenate metabolites biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
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CAS REGISTRY NUMBER
COMMENTARY
54989-39-8
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-methyl-3-glutathionyl-1,4-benzoquinone + NADPH
? + NADP+
-
Substrates: toluquinone thioether
Products: -
Products: -
?
2-methyl-3-glutathionyl-1,4-naphthoquinone + NADPH
? + NADP+
-
Substrates: menadione thioether
Products: -
Products: -
?
acid form of latanoprost + NADP+
? + NADPH
Substrates: -
Products: -
Products: -
?
glutathione-9-hydroxy-prostaglandin A1 thioether + NADP+
? + NADPH
-
Substrates: -
Products: -
Products: -
?
glutathione-prostaglandin A1 thioether + NADP+
? + NADPH
-
Substrates: PGA1-SG, excellent substrate for the placental enzyme
Products: -
Products: -
?
prostaglandin A1 + NADP+
15-oxoprostaglandin A1 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin B1 + NADP+
15-oxoprostaglandin B1 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin E1 + NADP+
15-keto-prostaglandin E1 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin E2 + NADP+
15-oxoprostaglandin E2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin I2 + NADP+
? + NADPH
-
Substrates: poor substrate for the enzyme
Products: -
Products: -
?
additional information
?
-
-
Substrates: the trans-dihydrodiols trans-dihydroxy-4,5-dihydrobenzo[alpha]pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene, trans-3,4-dihydroxy-3,4-dihydrobenz[alpha]anthracene and its 7-methyl, 12-methyl, and 7,12-dimethyl derivatives are not substrates for the enzyme
Products: -
Products: -
?
prostaglandin E2 + NADPH + H+
prostaglandin F2 + NADP+
-
Substrates: -
Products: -
Products: -
?
prostaglandin E2 + NADPH + H+
prostaglandin F2 + NADP+
-
Substrates: -
Products: -
Products: -
r
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
Substrates: -
Products: -
Products: -
?
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
-
Substrates: biological inactivation of prostaglandins is mediated by the enzyme
Products: -
Products: -
r
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
Substrates: -
Products: -
Products: -
?
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
-
Substrates: -
Products: -
Products: -
?
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
-
Substrates: -
Products: -
Products: -
r
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
Substrates: -
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
prostaglandin E2 + NADP+
15-oxoprostaglandin E2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1-glutathionyl-2-hydroxy-3(allyloxy)propane
-
competitive inhibition of prostaglandin B1 oxidation
glutathione-9-hydroxy-prostaglandin A1 thioether
-
inhibition of polycyclic aromatic hydrocarbon quinone reduction
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.0061
substrate prostaglandin F2alpha, cosubstrate NAD+, pH 7.0, 25°C
0.0098
substrate prostaglandin E2, cosubstrate NADP+, pH 7.0, 25°C
0.0243
substrate prostaglandin F2alpha, cosubstrate NADP+, pH 7.0, 25°C
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A0A341CHQ2_NEOAA
356
0
39027
TrEMBL
-
A0A4U1EAU6_MONMO
106
0
11595
TrEMBL
other Location (Reliability: 5)
A0A4W2DN11_BOBOX
356
0
38923
TrEMBL
Secretory Pathway (Reliability: 1)
A0A5F7ZH47_MACMU
412
0
44437
TrEMBL
other Location (Reliability: 1)
A0A7F8RVH3_LEPWE
272
0
29911
TrEMBL
other Location (Reliability: 2)
A0A7J8AD81_RHIFE
167
0
18643
TrEMBL
other Location (Reliability: 2)
A0A8C0PH65_CANLF
552
0
61460
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8C0PJ57_CANLF
387
0
42940
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8C0PNX5_CANLF
512
0
57076
TrEMBL
other Location (Reliability: 2)
A0A8C2VCT8_CHILA
197
0
21556
TrEMBL
Secretory Pathway (Reliability: 4)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Westbrook, C.; Lin, Y.M.; Jarabak, J.
NADP-linked 15-hydroxyprostaglandin dehydrogenase from human placenta: partial purification and characterization of the enzyme and identification of an inhibitor in placental tissue
Biochem. Biophys. Res. Commun.
76
943-949
1977
Homo sapiens
brenda
Wong, P.Y.K.; McGiff, J.C.
Detection of 15-hydroxyprostaglandin dehydrogenase in bovine mesenteric blood vessels
Biochim. Biophys. Acta
500
436-439
1977
Bos taurus
brenda
Jarabak, J.; Fried, J.
Comparison of substrate specificities of the human placental NAD-and NADP-linked 15-hydroxyprostaglandin dehydrogenases
Prostaglandins
18
241-246
1979
Homo sapiens
brenda
Levasseur, S.; Friedman, Y.; Burke, G.
Prostaglandin metabolism in the rat adrenal cortex: Characterization of prostaglandin-9-ketoreductase and 15-hydroxyprostaglandin dehydrogenase
Biochem. Biophys. Res. Commun.
95
236-242
1980
Homo sapiens, Platyrrhini, Rattus norvegicus
brenda
Chang, D.B.G; Sun, M.; Tai, H.H.
Prostaglandin-9-ketoreductase and type II 15-hydroxyprostaglandin dehydrogenase from swine kidney are alternate activities of a single enzyme protein
Biochem. Biophys. Res. Commun.
99
745-751
1981
Homo sapiens, Sus scrofa
brenda
Tai, H.H.; Chang, D.B.G.
Purification of NADP+/NADPH-dependent 15-hydroxyprostaglandin dehydrogenase and prostaglandin 9-ketoreductase from porcine kidney
Methods Enzymol.
86
142-147
1982
Sus scrofa
brenda
Chung, H.; Fried, J.; Williams-Ashman, E.; Jarabak, J.
Glutathione mixed disulfide inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase
Prostaglandins
33
383-390
1987
Homo sapiens
brenda
Chung, H.; Harvey, R.G.; Armstrong, R.N.; Jarabak, J.
Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase
J. Biol. Chem.
262
12448-12451
1987
Homo sapiens
brenda
Wermuth, B.
NADP-dependent 15-hydroxyprostaglandin dehydrogenase is homologous to NAD-dependent 15-hydroxyprostaglandin dehydrogenase and other short-chain alcohol dehydrogenases
Prostaglandins
44
5-9
1992
Homo sapiens
brenda
Krook, M.; Ghosh, D.; Duax, W.; Jrnvall, H.
Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase)
FEBS Lett.
322
139-142
1993
Homo sapiens
brenda
Fujimori, K.; Okada, T.; Urade, Y.
Expression of NADP(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase mRNA in Monkey Ocular Tissues and Characterization of Its Recombinant Enzyme
J. Biochem.
131
383-389
2002
Macaca fascicularis (Q8MI29)
brenda
Krook, M.; Ghosh, D.; Stromberg, R.; Carlquist, M.; Jornvall, H.
Carboxyethyllysine in a protein: Native carbonyl reductase/NADP+-dependent prostaglandin dehydrogenase
Proc. Natl. Acad. Sci. USA
90
502-506
1993
Homo sapiens
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.197)
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