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Information on EC 1.1.1.196 - 15-hydroxyprostaglandin-D dehydrogenase (NADP+)
for references in articles please use BRENDA:EC1.1.1.196
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)
IUBMB Comments
Specific for prostaglandins D [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)].
The enzyme appears in viruses and cellular organisms
Reaction Schemes
showSynonyms
prostaglandin d2 dehydrogenase, nadp+-dependent 15-hydroxyprostaglandin dehydrogenase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
15-hydroxy PGD2 dehydrogenase
-
-
-
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15-hydroxy prostaglandin dehydrogenase (NADP+)
-
-
-
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dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)
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dehydrogenase, prostaglandin D2
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-
-
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NADP+-dependent 15-hydroxyprostaglandin dehydrogenase
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-
-
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NADP+-linked 15-hydroxyprostaglandin dehydrogenase
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-
-
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NADP+-linkedprostaglandin D2 dehydrogenase
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-
-
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NADP+-specific 15-hydroxyprostaglandindehydrogenase
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NADP-PGD2 dehydrogenase
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prostaglandin D2 dehydrogenase
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prostaglandin-D 15-dehydrogenase (NADP+)
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+ = (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH + H+
specific for prostaglandins D cf.EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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-
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reduction
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-
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-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
C20 prostanoid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase
Specific for prostaglandins D [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)].
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CAS REGISTRY NUMBER
COMMENTARY
84399-95-1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
prostaglandin A2 + NADP+
15-ketoprostaglandin A2 + NADPH + H+
-
Substrates: poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2
Products: -
Products: -
?
prostaglandin B2 + NADP+
15-ketoprostaglandin B2 + NADPH + H+
-
Substrates: poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2
Products: -
Products: -
?
prostaglandin D1 + NADP+
15-ketoprostaglandin D1 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin D3 + NADP+
15-ketoprostaglandin D3 + NADPH + H+
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Substrates: poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2
Products: -
Products: -
?
prostaglandin I2 + NADP+
15-ketoprostaglandin I2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin D2 + NADP+
15-ketoprostaglandin D2 + NADPH + H+
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Substrates: -
Products: -
Products: -
?
prostaglandin D2 + NADP+
15-ketoprostaglandin D2 + NADPH + H+
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Substrates: specific inactivation of prostaglandin D2 in the brain, in the central nervous system and also in blood platelets
Products: -
Products: -
?
prostaglandin D2 + NADP+
15-ketoprostaglandin D2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin D2 + NADP+
15-ketoprostaglandin D2 + NADPH + H+
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Substrates: specific inactivation of prostaglandin D2 in the brain, in the central nervous system and also in blood platelets
Products: -
Products: -
?
prostaglandin D2 + NADP+
15-ketoprostaglandin D2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin E2 + NADP+
15-ketoprostaglandin E2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin E2 + NADP+
15-ketoprostaglandin E2 + NADPH + H+
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Substrates: poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2
Products: -
Products: -
?
prostaglandin F2alpha + NADP+
15-ketoprostaglandin F2alpha + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin F2alpha + NADP+
15-ketoprostaglandin F2alpha + NADPH + H+
-
Substrates: poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
prostaglandin D2 + NADP+
15-ketoprostaglandin D2 + NADPH + H+
-
Substrates: specific inactivation of prostaglandin D2 in the brain, in the central nervous system and also in blood platelets
Products: -
Products: -
?
prostaglandin D2 + NADP+
15-ketoprostaglandin D2 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
prostaglandin D2 + NADP+
15-ketoprostaglandin D2 + NADPH + H+
-
Substrates: specific inactivation of prostaglandin D2 in the brain, in the central nervous system and also in blood platelets
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Myeloproliferative Disorders
Platelet prostaglandin D2 dehydrogenase in patients with myeloproliferative disorders.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A0A2K5VR43_MACFA
415
0
45083
TrEMBL
Mitochondrion (Reliability: 4)
A0A341CHQ2_NEOAA
356
0
39027
TrEMBL
-
A0A4W2DN11_BOBOX
356
0
38923
TrEMBL
other Location (Reliability: 4)
A0A5N3WKD3_MUNMU
223
0
24362
TrEMBL
other Location (Reliability: 4)
A0A8C0PJ57_CANLF
387
0
42940
TrEMBL
other Location (Reliability: 4)
A0A8C5W2R8_MICMU
248
0
27530
TrEMBL
other Location (Reliability: 3)
A0A8C6AFK1_MONMO
356
0
39008
TrEMBL
other Location (Reliability: 1)
A0AAX6STU6_HETGA
136
0
15079
TrEMBL
other Location (Reliability: 3)
M1EHV1_MUSPF
202
0
22462
TrEMBL
Secretory Pathway (Reliability: 2)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
28000
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7
-
most stable at pH 7 with 54% loss of activity, loses 100% activity at pH 5, 70% at pH 6, 76% at pH 8 and 100% at pH 9
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
enzyme is quite unstable at the low protein concentrations less than 10 mg/ml, sulfhydryl reagents like dithiothreitol, 2-mercaptoethanol and reduced glutathione protect the enzyme from inactivation
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Watanabe, K.; Shimizu, T.; Iguchi, S.; Wakatsuka, H.; Hayashi, M.; Hayaishi, O.
An NADP-linked prostaglandin D dehydrogenase in swine brain
J. Biol. Chem.
255
1779-1782
1980
Sus scrofa
brenda
Shimizu, T.; Watanabe, K.; Tokumoto, H.; Hayaishi, O.
Isolation of NADP+-dependent PGD2-specific 15-hydroxyprostaglandin dehydrogenase from swine brain
Methods Enzymol.
86
147-152
1982
Sus scrofa
brenda
Tokumoto, H.; Watanabe, K.; Fukushima, D.; Shimizu, T.; Hayaishi, O.
An NADP-linked 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin D2 from swine brain
J. Biol. Chem.
257
13576-13580
1982
Homo sapiens, Sus scrofa
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.196)
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