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IUBMB Comments Acts on hydroxycyclohexanecarboxylates that have an equatorial carboxy group at C-1, an axial hydroxy group at C-3 and an equatorial hydroxy or carbonyl group at C-4, including (-)-quinate and (-)-shikimate.
Synonyms
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(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase
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dihydroxycyclohexanecarboxylate dehydrogenase
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(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH + H+
Acts on hydroxycyclohexanecarboxylates that have an equatorial carboxyl group at C-1, an axial hydroxyl group at C-3 and an equatorial hydroxyl group or carbonyl group at C-4, including (-)-quinate and (-)-shikimate
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(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase
Acts on hydroxycyclohexanecarboxylates that have an equatorial carboxy group at C-1, an axial hydroxy group at C-3 and an equatorial hydroxy or carbonyl group at C-4, including (-)-quinate and (-)-shikimate.
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(+)t-3,t-4-dihydroxycyclohexanecarboxylate + NAD+
4-hydroxy-3-oxocyclohexanecarboxylate + NADH + H+
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Substrates: -
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(+-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate + NAD+
(+-)t-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH
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Substrates: -
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(-)-dihydroshikimate + NAD+
? + NADH
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Substrates: -
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(-)-quinate + NAD+
3-dehydroquinate + NADH + H+
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Substrates: -
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(-)-shikimate + NAD+
(-)-3-dehydroshikimate + NADH + H+
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Substrates: more rapidly oxidized than other acids
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(-)t-3,t-4-dihydroxycyclohexanecarboxylate + NAD+
4-hydroxy-3-oxocyclohexanecarboxylate + NADH + H+
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Substrates: -
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(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+
(1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH
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Substrates: -
r
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(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+
(1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH
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Substrates: -
r
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NAD+
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can not be replaced by NADP+
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1.55
(+-)t-3,t-4-dihydroxycyclohexanecarboxylate
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0.52
(-)-Dihydroshikimate
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0.74
(-)t-3,t-4-dihydroxycyclohexanecarboxylate
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0.26
NAD+
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with (-)-shikimate
0.34
NAD+
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with (+-)t-3,t-4-dihydroxycyclohexanecarboxylate and (-)-dihydroshikimate
0.36
NAD+
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with (-)t-3,t-4-dihydroxycyclohexanecarboxylate
0.45
NAD+
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with (-)-quinate
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10 - 10.1
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oxidative direction
7.2
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reductive direction
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6 - 8
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active within, reductive direction
6.9 - 11.4
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active within, oxidative direction
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brenda
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Highest Expressing Human Cell Lines
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to homogeneity, chromatography techniques
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Whiting, G.C.; Coggins, R.A.
A new nicotinamide-adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (-)t-3,t-4-dihydrocyclohexane-c-1carboxylate
Biochem. J.
141
35-42
1974
Lactiplantibacillus plantarum
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