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Information on EC 1.1.1.138 - mannitol 2-dehydrogenase (NADP+)
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EC Tree
1.1.1.138 mannitol 2-dehydrogenase (NADP+)Specify your search results
Word Map
- 1.1.1.138
- spindle
-
checkpoint
- d-fructose
- kinetochore
-
anaphase
- cladosporium
- bub3
-
kinetochore-microtubule
-
1.1.1.67
- herbarum
- l-xylulose
- d-arabinitol
- gluconobacter
- jecorina
- mad3
-
ige-binding
- hypocrea
-
unattached
- synthesis
- analysis
- biotechnology
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
mad1p, d-mannitol dehydrogenase, cla h 8, psldr, gox1432, nadp-dependent mannitol dehydrogenase, d-mannitol 2-dehydrogenase, tbmdh, lrmdh, nadp-mannitol dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
D-mannitol 2-dehydrogenase
D-mannitol dehydrogenase, NADP-dependent
LXR1
mannitol 2-dehydrogenase
Mannitol 2-dehydrogenase [NADP+]
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-
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mannitol dehydrogenase
mannitol dehydrogenase (NADP+)
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-
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mannitol dehydrogenase (nicotinamide dinucleotide phosphate)
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-
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MDH
MtDH
NADP-dependent mannitol dehydrogenase
additional information
the enzyme defines a subfamily within the polyol-specific medium chain dehydrogenases
mannitol dehydrogenase
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-mannitol + NADP+ = D-fructose + NADPH + H+
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-
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D-mannitol + NADP+ = D-fructose + NADPH + H+
sequential ordered bi-bi mechanism
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D-mannitol + NADP+ = D-fructose + NADPH + H+
sequential ordered bi bi mechanism
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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-
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reduction
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
D-mannitol:NADP+ 2-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
37250-68-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-deoxy-6-methyl-D-glucitol + NADP+
1-deoxy-6-methyl-D-glucose + NADPH
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poorer substrate than D-glucitol
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?
1-deoxy-6-methyl-D-mannitol + NADP+
1-deoxy-6-methyl-D-fructose + NADPH
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poorer substrate than D-mannitol
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?
1-deoxy-D-glucitol + NADP+
1-deoxy-D-glucose + NADPH
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poorer substrate than glucitol
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?
1-deoxy-D-mannitol + NADP+
1-deoxy-D-fructose + NADPH
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poorer substrate than D-mannitol
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?
D-mannitol + 3-acetylpyridine adenine dinucleotide phosphate
D-fructose + 3-acetylpyridine adenine dinucleotide phosphate(H)
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7.5% of the activity compared to NADP+
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?
D-mannitol + thio-NADP+
D-fructose + thio-NADPH
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30% of the activity compared to NADP+
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?
L-sorbitol + NADP+
L-sorbose + NADPH + H+
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21% of the activity with D-mannitol
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-
r
perseitol + NADP+
? + NADPH
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6% of the activity compared to D-mannitol
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?
D-arabinitol + NADP+
D-xylulose + NADPH + H+
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3% of the activity compared to D-mannitol
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?
D-arabinitol + NADP+
D-xylulose + NADPH + H+
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substrate must have a primary hydroxyl group at C1, an R hydroxyl at C2, an R hydroxyl at C3, an R hydroxyl at C4 and either an R or S or primary hydroxyl at C5
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?
D-mannitol + NAD+
D-fructose + NADH + H+
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less than 0.05% of the activity compared to NADP+
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?
D-mannitol + NAD+
D-fructose + NADH + H+
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less than 25% of the activity with NADP+
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r
D-mannitol + NADP+
D-fructose + NADPH + H+
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mannitol serves as storage carbon, plays a critical role in growth, fruit body development, osmoregulation and salt tolerance
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r
D-mannitol + NADP+
D-fructose + NADPH + H+
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involved in the mannitol cycle, important for NADPH regeneration
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?
D-mannitol + NADP+
D-fructose + NADPH + H+
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substrate must have a primary hydroxyl group at C1, an R hydroxyl at C2, an R hydroxyl at C3, an R hydroxyl at C4 and either an R or S or primary hydroxyl at C5
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?
D-mannitol + NADP+
D-fructose + NADPH + H+
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involved in the mannitol cycle, important for NADPH regeneration
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?
D-mannitol + NADP+
D-fructose + NADPH + H+
Cenococcum graniforme
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involved in the mannitol cycle, important for NADPH regeneration
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?
D-mannitol + NADP+
D-fructose + NADPH + H+
Ceratocystis multiannulata
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involved in the mannitol cycle, important for NADPH regeneration
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?
D-mannitol + NADP+
D-fructose + NADPH + H+
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involved in the mannitol cycle, important for NADPH regeneration
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?
D-mannitol + NADP+
D-fructose + NADPH + H+
Diplodia viticola Desm.
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more specific for D-mannitol than for sorbitol or D-arabinitol
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r
D-mannitol + NADP+
D-fructose + NADPH + H+
Diplodia viticola Desm.
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involved in the mannitol cycle, important for NADPH regeneration
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r
D-mannitol + NADP+
D-fructose + NADPH + H+
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involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
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involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
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involved in the mannitol cycle, important for NADPH regeneration
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?
D-mannitol + NADP+
D-fructose + NADPH + H+
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only the mutant enzymes D69A amd E68K, the wild-type enzyme utilizes NAD(H) as cofactor, EC 1.1.1.67
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r
D-mannitol + NADP+
D-fructose + NADPH + H+
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less than 3% the rate of fructose reduction
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r
D-mannitol + NADP+
D-fructose + NADPH + H+
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involved in the mannitol cycle, important for NADPH regeneration
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?
D-mannitol + NADP+
D-fructose + NADPH + H+
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involved in the mannitol cycle, important for NADPH regeneration
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?
D-mannitol + NADP+
D-fructose + NADPH + H+
enzyme regulation mode, overview
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r
D-mannitol + NADP+
D-fructose + NADPH + H+
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the enzyme has a dual role in mannitol metabolism, D-mannitol is the main storage sugar in spores
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r
D-mannitol + NADP+
D-fructose + NADPH + H+
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the reverse reaction occurs only when D-fructose is provided as substrate, and is preferred
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r
D-sorbitol + NADP+
D-sorbose + NADPH + H+
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21% of the activity compared to D-mannitol
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?
L-arabinitol + NADP+
L-xylulose + NADPH + H+
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2% of the activity compared to D-mannitol
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?
L-arabinitol + NADP+
L-xylulose + NADPH + H+
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5% of the activity compared to D-mannitol
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?
L-sorbitol + NADP+
L-sorbose + NADPH
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7.7% of the activity compared to D-mannitol
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?
L-sorbitol + NADP+
L-sorbose + NADPH
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substrate must have a primary hydroxyl group at C1, an R hydroxyl at C2, an R hydroxyl at C3, an R hydroxyl at C4 and either an R or S or primary hydroxyl at C5
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r
L-sorbitol + NADP+
L-sorbose + NADPH
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4% of the activity compared to D-mannitol
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r
L-sorbitol + NADP+
L-sorbose + NADPH
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4% of the activity compared to D-mannitol
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r
L-sorbitol + NADP+
L-sorbose + NADPH
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4% of the activity compared to D-mannitol
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r
additional information
?
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the enzyme is the major allergen in the organism causing allergic reaction e.g. in humans
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?
additional information
?
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the enzyme is the major allergen in the organism causing allergic reaction e.g. in humans
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?
additional information
?
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the enzyme is able to reduce D-fructose, L-sorbose, and 5-keto D-gluconate in the presence of NADPH as an electron donor
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?
additional information
?
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no substrate: glucose, xylose, arabinose
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?
additional information
?
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specific for transferring the 4-pro-S hydrogen from NAD(P)H
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?
additional information
?
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specific for transfer of 4-pro-S hydrogen of NADPH
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?
additional information
?
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the enzyme has a high preference only for D-fructose and D-mannitol, while D-mannose, D-arabinose, D-ribose, D-glucose, D-galactose, D-xylose, D-sorbose and D-sorbitol show only poor activity
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?
additional information
?
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the enzyme has a high preference only for D-fructose and D-mannitol, while D-mannose, D-arabinose, D-ribose, D-glucose, D-galactose, D-xylose, D-sorbose and D-sorbitol show only poor activity
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-mannitol + NADP+
D-fructose + NADPH + H+
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mannitol serves as storage carbon, plays a critical role in growth, fruit body development, osmoregulation and salt tolerance
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r
D-mannitol + NADP+
D-fructose + NADPH + H+
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involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
substrate must have a primary hydroxyl group at C1, an R hydroxyl at C2, an R hydroxyl at C3, an R hydroxyl at C4 and either an R or S or primary hydroxyl at C5
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?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
Cenococcum graniforme
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involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
Ceratocystis multiannulata
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involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
Diplodia viticola Desm.
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more specific for D-mannitol than for sorbitol or D-arabinitol
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r
D-mannitol + NADP+
D-fructose + NADPH + H+
Diplodia viticola Desm.
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involved in the mannitol cycle, important for NADPH regeneration
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
enzyme regulation mode, overview
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
the enzyme has a dual role in mannitol metabolism, D-mannitol is the main storage sugar in spores
-
-
r
additional information
?
-
the enzyme is the major allergen in the organism causing allergic reaction e.g. in humans
-
-
?
additional information
?
-
-
the enzyme is the major allergen in the organism causing allergic reaction e.g. in humans
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD(P)+
-
NADP+ is the preferred cofactor in the forward reaction
NAD(P)H
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NADPH is the preferred cofactor in the reverse reaction