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Synonyms
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2-deoxy-D-gluconate 3-dehydrogenase
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2-deoxygluconate dehydrogenase
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2-deoxygluconic acid dehydrogenase
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2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+
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MetaCyc
2-deoxy-D-glucose 6-phosphate degradation
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2-deoxy-D-gluconate:NAD+ 3-oxidoreductase
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2-deoxy-D-gluconate + NAD+
3-dehydro-2-deoxy-D-gluconate + NADH
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Substrates: -
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2-deoxy-D-gluconate + NAD+
3-dehydro-2-deoxy-D-gluconate + NADH
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NAD+
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can not be replaced by NADP+
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NAD+
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inhibition at high concentrations
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1.54 - 5
2-deoxy-D-gluconate
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inducible enzyme synthesis by growth in 2-deoxy-D-gluconate containing medium
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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malfunction
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when grown in the presence of galacturonate or glucuronate, kduID deficient Escherichia coli have a 30% to 80% lower maximal cell density and 1.5 to 2fold longer doubling times under osmotic stress conditions than wild type Escherichia coli
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C5BY10_BEUC1
Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / CCUG 43141 / JCM 11478 / NBRC 16432 / NCIMB 13614 / HKI 0122)
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25437
TrEMBL
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Q53W82_THET8
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
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25673
TrEMBL
other Location (Reliability: 3 )
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galacturonate and glucuronate induced kduD and kduI gene expression 3fold and 7 to 11fold, respectively, under aerobic conditions as well as 9 to 20fold and 19 to 54fold, respectively, under anaerobic conditions
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Eichhorn, M.M.; Cynkin, M.A.
Microbial metabolism of 2-deoxyglucose; 2-deoxygluconic acid dehydrogenase
Biochemistry
4
159-165
1965
Pseudomonas sp.
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Rothe, M.; Alpert, C.; Loh, G.; Blaut, M.
Novel insights into E. colis hexuronate metabolism: KduI facilitates the conversion of galacturonate and glucuronate under osmotic stress conditions
PLoS ONE
8
e56906
2013
Escherichia coli
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