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Information on EC 1.1.1.122 - D-threo-aldose 1-dehydrogenase
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EC Tree
1.1.1.122 D-threo-aldose 1-dehydrogenaseIUBMB Comments
Acts on L-fucose, D-arabinose and L-xylose; the animal enzyme was also shown to act on L-arabinose, and the enzyme from Pseudomonas caryophylli on L-glucose.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
l-fucose dehydrogenase, d-threo-aldose 1-dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(2S,3R)-aldose dehydrogenase
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FDH
L-fucose (D-arabinose) dehydrogenase
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L-fucose dehydrogenase
Sso1300
L-fucose dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH + H+
Acts on L-fucose, D-arabinose and L-xylose. The animal enzyme was also shown to act on L-arabinose, and the enzyme from Pseudomonas caryophylli on L-glucose
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
D-threo-aldose:NAD+ 1-oxidoreductase
Acts on L-fucose, D-arabinose and L-xylose; the animal enzyme was also shown to act on L-arabinose, and the enzyme from Pseudomonas caryophylli on L-glucose.
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CAS REGISTRY NUMBER
COMMENTARY
9082-70-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-ribose + NAD+
? + NADH
Ovis aries aries
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10% of the activity compared to L-fucose or D-arabinose
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?
3-amino-3-deoxy-D-arabinose + NAD+
3-amino-3-deoxy-D-arabino-1,5-lactone + NADH
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15% of the activity compared to L-fucose
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?
3-amino-3-deoxy-D-arabinose + NAD+
3-amino-3-deoxy-D-arabino-1,5-lactone + NADH + H+
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-
-
-
r
D-ribose + NAD+
? + NADH
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8% of the activity compared to D-arabinose or L-xylose
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?
L-galactose + NADP+
?
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L-galactose is a poor substrate with 11% activity compared to L-fucose
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?
L-glucose + NAD+
L-glucono-1,5-lactone + NADH
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68% of the activity compared to D-arabinose or L-xylose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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irreversible because of spontaneous conversion to L-fuconic acid during incubation
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ir
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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ir
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
Ovis aries aries
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ordered bi-bi-reaction mechanism
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
Ovis aries aries
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
Ovis aries aries
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose. The enzyme is specific for sugars with D-arabinose-type hydroxyl group stereo-configurations at C3 and C4. This configuration is shared among the hexoses L-fucose (6-deoxy-L-galactose) and L-galactose, and the pentose D-ribose. Although the highest activity is observed with L-fucose in combination with NAD+, the remaining sugars are oxidized at higher rates using NADP+
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose. The enzyme is specific for sugars with D-arabinose-type hydroxyl group stereo-configurations at C3 and C4. This configuration is shared among the hexoses L-fucose (6-deoxy-L-galactose) and L-galactose, and the pentose D-ribose. Although the highest activity is observed with L-fucose in combination with NAD+, the remaining sugars are oxidized at higher rates using NADP+
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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73% of the activity compared to D-arabinose or L-xylose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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71% of the activity compared to L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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74.5% of the activity compared to L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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74.5% of the activity compared to L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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84% of the activity compared to L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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66% of the activity compared to L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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100% activity
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?
D-arabinose + NADP+
D-arabinolactone + NADPH + H+
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good substrate with 65% activity compared to L-fucose
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?
D-arabinose + NADP+
D-arabinolactone + NADPH + H+
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good substrate with 65% activity compared to L-fucose
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?
D-galactose + NAD+
D-galactono-1,5-lactone + NADH + H+
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r
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
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2.1% of the activity compared to L-fucose
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?
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
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9% of the activity compared to D-arabinose or L-xylose
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?
L-fucose + NADP+
L-fuconolactone + NADPH + H+
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good substrate
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?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
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57% of the activity compared to L-fucose
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?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
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59.6% of the activity compared to L-fucose
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?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
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59.6% of the activity compared to L-fucose
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?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
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13% of the activity compared to L-fucose
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?
L-xylose + NAD+
L-xylono-1,5-lactone + NADH
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4% of the activity compared to L-fucose
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?
additional information
?
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no activity with D-glucose, D-fructose, D-galactose, L-arabinose, D-mannose, L-rhamnose, D-xylose, maltose, sucrose, and lactose
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?
additional information
?
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no activity with D-glucose, D-fructose, D-galactose, L-arabinose, D-mannose, L-rhamnose, D-xylose, maltose, sucrose, and lactose
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-ribose + NAD+
? + NADH
Ovis aries aries
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10% of the activity compared to L-fucose or D-arabinose
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?
3-amino-3-deoxy-D-arabinose + NAD+
3-amino-3-deoxy-D-arabino-1,5-lactone + NADH
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15% of the activity compared to L-fucose
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?
D-ribose + NAD+
? + NADH
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8% of the activity compared to D-arabinose or L-xylose
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?
L-glucose + NAD+
L-glucono-1,5-lactone + NADH
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68% of the activity compared to D-arabinose or L-xylose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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irreversible because of spontaneous conversion to L-fuconic acid during incubation
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ir
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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ir
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
Ovis aries aries
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ordered bi-bi-reaction mechanism
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
Ovis aries aries
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
Ovis aries aries
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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73% of the activity compared to D-arabinose or L-xylose
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?
6-deoxy-L-galactose + NAD+
6-deoxy-L-galactono-1,5-lactone + NADH
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i.e. L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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71% of the activity compared to L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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74.5% of the activity compared to L-fucose
-
?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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74.5% of the activity compared to L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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84% of the activity compared to L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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66% of the activity compared to L-fucose
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?
D-arabinose + NAD+
D-arabinono-1,4-lactone + NADH
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100% activity
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?
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
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2.1% of the activity compared to L-fucose
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?
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
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9% of the activity compared to D-arabinose or L-xylose
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?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
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57% of the activity compared to L-fucose
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?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
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59.6% of the activity compared to L-fucose
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?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
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59.6% of the activity compared to L-fucose
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?
L-galactose + NAD+
L-galactono-1,5-lactone + NADH
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13% of the activity compared to L-fucose
-
?
L-xylose + NAD+
L-xylono-1,5-lactone + NADH
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4% of the activity compared to L-fucose
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?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD+
the enzyme is specific for sugars with D-arabinose-type hydroxyl group stereo-configurations at C3 and C4. This configuration is shared among the hexoses L-fucose (6-deoxy-L-galactose) and L-galactose, and the pentose D-ribose. Although the highest activity is observed with L-fucose in combination with NAD+, the remaining sugars are oxidized at higher rates using NADP+
NADP+
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30% of the activity compared to NAD+, L-fucose dehydrogenation
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Zn2+
Zn2+
contains two endogenous zinc ions per subunit.A zinc ion is bound in the loop that protrudes from the catalytic domain. This zinc is tetrahedrally coordinated by residues D94, C97, C100 and C108
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Neoplasms
Rapid, simple enzymatic assay of free L-fucose in serum and urine, and its use as a marker for cancer, cirrhosis, and gastric ulcers.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE