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2-amino-2-deoxy-D-glucose + NAD+
? + NADH
-
26% activity compared to D-glucose in combination with NAD+
-
-
?
2-amino-2-deoxy-D-glucose + NADP+
? + NADPH
-
5% activity compared to D-glucose in combination with NAD+
-
-
?
2-deoxy-D-galactose + NAD+
2-deoxy-D-galactono-1,5-lactone + NADH
-
-
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
2-deoxy-D-glucose + NADP+
? + NADPH
-
25% activity compared to D-glucose in combination with NAD+
-
-
?
3,6-dideoxy-D-galactose + NAD+
3,6-dideoxy-D-galactono-1,5-lactone + NADH
-
-
-
-
?
6-deoxy-D-galactose + NAD+
6-deoxy-D-galactono-1,5-lactone + NADH
-
-
-
-
?
6-deoxy-D-glucose + NAD+
6-deoxy-D-glucono-1,5-lactone + NADH + H+
6-deoxy-D-glucose + NADP+
? + NADPH
-
9% activity compared to D-glucose in combination with NAD+
-
-
?
beta-D-galactose + NAD+
D-galactono-1,5-lactone + NADH
AHI17928.1
-
-
-
?
D-allose + NAD+
D-allono-1,5-lactone + NADH
-
-
-
-
?
D-altrose + NAD+
D-altrono-1,5-lactone + NADH
-
-
-
-
?
D-altrose + NAD+
D-altrono-1,5-lactone + NADH + H+
-
5% activity compared to D-glucose in combination with NAD+
-
-
?
D-altrose + NADP+
? + NADPH
-
12% activity compared to D-glucose in combination with NAD+
-
-
?
D-fucose + NAD+
D-fucono-1,5-lactone + NADH + H+
-
-
-
-
r
D-galactose + NAD+
D-galactono-1,5-lactone + NADH
D-galactose + NAD+
D-galactono-1,5-lactone + NADH + H+
-
15% activity compared to D-glucose in combination with NAD+
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
D-gulose + NAD+
? + NADH
-
8% activity compared to D-glucose in combination with NAD+
-
-
?
D-gulose + NADP+
? + NADPH
-
12% activity compared to D-glucose in combination with NAD+
-
-
?
D-idose + NAD+
? + NADH
-
65% activity compared to D-glucose in combination with NAD+
-
-
?
D-idose + NADP+
? + NADPH
-
12% activity compared to D-glucose in combination with NAD+
-
-
?
D-mannose + NAD+
D-manno-1,5-lactone + NADH
D-mannose + NADP+
? + NADPH
-
4% activity compared to D-glucose in combination with NAD+
-
-
?
D-ribose + NADP+
? + NADPH
-
4% activity compared to D-glucose in combination with NAD+
-
-
?
D-xylose + NAD+
? + NADH
-
26% activity compared to D-glucose in combination with NAD+
-
-
?
D-xylose + NADP+
? + NADPH
-
28% activity compared to D-glucose in combination with NAD+
-
-
?
additional information
?
-
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
12% activity compared to D-glucose in combination with NAD+
-
-
?
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
-
12% activity compared to D-glucose in combination with NAD+
-
-
?
6-deoxy-D-glucose + NAD+
6-deoxy-D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
6-deoxy-D-glucose + NAD+
6-deoxy-D-glucono-1,5-lactone + NADH + H+
-
66% activity compared to D-glucose in combination with NAD+
-
-
?
6-deoxy-D-glucose + NAD+
6-deoxy-D-glucono-1,5-lactone + NADH + H+
-
66% activity compared to D-glucose in combination with NAD+
-
-
?
D-galactose + NAD+
D-galactono-1,5-lactone + NADH
-
-
-
-
?
D-galactose + NAD+
D-galactono-1,5-lactone + NADH
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
-
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
100% activity
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
-
100% activity
-
-
?
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
AHI17928.1
the enzyme prefers NADP+ as coenzyme to NAD+
-
-
?
D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
-
-
-
-
?
D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
-
-
-
-
?
D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
-
9% activity compared to D-glucose in combination with NAD+
-
-
?
D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
-
9% activity compared to D-glucose in combination with NAD+
-
-
?
D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
AHI17928.1
-
-
-
?
D-mannose + NAD+
D-manno-1,5-lactone + NADH
-
-
-
-
?
D-mannose + NAD+
D-manno-1,5-lactone + NADH
-
-
-
-
?
additional information
?
-
-
no activity with: D-glucuronic acid, D-galacturonic acid, D-galactose 6-phosphate, D-glucose 6-phosphate, D-glucosamine, N-acetyl-D-glucosamine, 6-deoxy-D-allose, 6-iodo-6-deoxy-D-galactose, 2-acetamide-6-deoxy-D-allose, 2-acetamido-6-deoxy-D-altrose
-
-
?
additional information
?
-
-
no activity with: D-glucuronic acid, D-galacturonic acid, D-galactose 6-phosphate, D-glucose 6-phosphate, D-glucosamine, N-acetyl-D-glucosamine, 6-deoxy-D-allose, 6-iodo-6-deoxy-D-galactose, 2-acetamide-6-deoxy-D-allose, 2-acetamido-6-deoxy-D-altrose
-
-
?
additional information
?
-
-
no activity towards D-mannose,D-galactose, and D-ribose in combination with NAD+
-
-
?
additional information
?
-
-
no activity towards D-mannose,D-galactose, and D-ribose in combination with NAD+
-
-
?
additional information
?
-
AHI17928.1
the enzyme shows no activity towards D-xylose, D-mannose, D-maltose, glucose 6-phosphate and sucrose
-
-
-
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Acrodynia
Identification and characterization of a Pantoea citrea gene encoding glucose dehydrogenase that is essential for causing pink disease of pineapple.
Dehydration
Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase.
Dehydration
The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus.
Galactosemias
Erroneous glucose recordings while using mutant variant of quinoprotein glucose dehydrogenase glucometer in a child with galactosemia.
glucose 1-dehydrogenase (nad+) deficiency
[Phosphate glucose dehydrogenase deficiency causing hyperbilirubinemia in the newborn]
Malaria
Analysis of the genetic variants of glucose-6-phosphate dehydrogenase in inhabitants of the 4th Nile cataract region in Sudan.
Pancreatitis
Peritoneal dialysis: a primary care perspective.
Photosensitivity Disorders
Biohydrogen production from sucrose using the visible light sensitization of artificial Zn chlorophyll-a.
Photosensitivity Disorders
Photoinduced biohydrogen production from biomass.
Photosensitivity Disorders
Visible light induced biohydrogen production from sucrose using the photosensitization of Mg chlorophyll-a.
Photosensitivity Disorders
Visible light-induced H2 production from cellulose using photosensitization of Mg chlorophyll a.
Starvation
Glucose dehydrogenase, glucose-6-phosphate dehydrogenase and hexokinase in liver of rainbow trout (Salmo gairdneri). Effects of starvation and temperature variations.
Starvation
[Variations of enzymatic activities in an asporogenic mutant of Bacillus megaterium for various nutritional deficiencies]
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22
D-galactose
-
in the presence of NADP+, in 100 mM triethanolamine/HCl buffer, 20 mM MgCl2, at 70°C
0.44
D-glucose
-
in the presence of NADP+, in 100 mM triethanolamine/HCl buffer, 20 mM MgCl2, at 70°C
7.48
D-glucose
AHI17928.1
pH 7.5, 40°C
8
D-glucose
-
in the presence of NAD+, in 100 mM triethanolamine/HCl buffer, 20 mM MgCl2, at 70°C
2.2
D-xylose
-
in the presence of NADP+, in 100 mM triethanolamine/HCl buffer, 20 mM MgCl2, at 70°C
68
D-xylose
-
in the presence of NAD+, in 100 mM triethanolamine/HCl buffer, 20 mM MgCl2, at 70°C
0.67
NAD+
AHI17928.1
pH 7.5, 40°C
1.2
NAD+
-
in the presence of D-glucose, in 100 mM triethanolamine/HCl buffer, 20 mM MgCl2, at 70°C
1.2
NAD+
-
in the presence of D-xylose, in 100 mM triethanolamine/HCl buffer, 20 mM MgCl2, at 70°C
0.03
NADP+
-
in the presence of D-galactose, in 100 mM triethanolamine/HCl buffer, 20 mM MgCl2, at 70°C
0.03
NADP+
-
in the presence of D-glucose, in 100 mM triethanolamine/HCl buffer, 20 mM MgCl2, at 70°C
0.03
NADP+
-
in the presence of D-xylose, in 100 mM triethanolamine/HCl buffer, 20 mM MgCl2, at 70°C
157.9
NADP+
AHI17928.1
pH 7.5, 40°C
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E170K
-
has enhanced stability when compared to the wild-type with half-life of ca. 9 min at 65°C. Stability dependence on salt concentration
E170K/Q252L
-
has enhanced stability when compared to the wild-type with half-life of ca. 5000 min at 65°C. The mutant demonstrates high stability regardless of salt-type at both water activities of 0.99 and 0.95
P45A/F155Y/V227A
-
has enhanced stability when compared to the wild-type with half-life of ca. 0.05 min at 65°C. Most labile variant has significantly lower stability in ethanol, acetone, and 1,4-dioxane than other variants
P45A/N46E/F155Y/E170K/V227A/W230F/Q252L
-
has enhanced stability when compared to the wild-type with half-life of ca. 5000 min at 65°C. The mutant demonstrates high stability regardless of salt-type at both water activities of 0.99 and 0.95
E170K
-
has enhanced stability when compared to the wild-type with half-life of ca. 9 min at 65°C. Stability dependence on salt concentration
-
E170K/Q252L
-
has enhanced stability when compared to the wild-type with half-life of ca. 5000 min at 65°C. The mutant demonstrates high stability regardless of salt-type at both water activities of 0.99 and 0.95
-
P45A/F155Y/V227A
-
has enhanced stability when compared to the wild-type with half-life of ca. 0.05 min at 65°C. Most labile variant has significantly lower stability in ethanol, acetone, and 1,4-dioxane than other variants
-
P45A/N46E/F155Y/E170K/V227A/W230F/Q252L
-
has enhanced stability when compared to the wild-type with half-life of ca. 5000 min at 65°C. The mutant demonstrates high stability regardless of salt-type at both water activities of 0.99 and 0.95
-
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DMSO
AHI17928.1
retains over 90% activity after incubation in organic solvent/buffer (1:1, v/v) system at 40°C and 220 rpm for 12 h
isopropanol
AHI17928.1
retains over 90% activity after incubation in organic solvent/buffer (1:1, v/v) system at 40°C and 220 rpm for 12 h
N,N-dimethylformamide
AHI17928.1
half-life of 3 h
SDS
-
a slow time-dependent decrease of activity is observed in the presence of 0.1% SDS
Acetone
-
stable in the presence of chaotropic agents and water-miscible organic solvents such as acetone
Acetone
-
stable in the presence of chaotropic agents and water-miscible organic solvents such as acetone
-
Ethanol
-
a slow time-dependent decrease of activity is observed in the presence of ethanol
Ethanol
-
a slow time-dependent decrease of activity is observed in the presence of ethanol
-
Ethanol
AHI17928.1
retains over 90% activity after incubation in organic solvent/buffer (1:1, v/v) system at 40°C and 220 rpm for 12 h
Methanol
-
stable in the presence of chaotropic agents and water-miscible organic solvents such as methanol
Methanol
-
stable in the presence of chaotropic agents and water-miscible organic solvents such as methanol
-
Methanol
AHI17928.1
retains over 90% activity after incubation in organic solvent/buffer (1:1, v/v) system at 40°C and 220 rpm for 12 h
urea
-
a slow time-dependent decrease of activity is observed in the presence of 4 M urea
urea
-
a slow time-dependent decrease of activity is observed in the presence of 4 M urea
-
additional information
-
2 M urea and 0.05% (w/v) SDS do not cause any loss of enzymic activity
additional information
-
2 M urea and 0.05% (w/v) SDS do not cause any loss of enzymic activity
-
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Hu, A.S.L.; Cline, A.L.
The regulation of some sugar dehydrogenases in a Pseudomonad
Biochim. Biophys. Acta
93
237-245
1964
Pseudomonas sp.
brenda
Kobayashi, Y.; Horikoshi, K.
Identification and growth characteristics of alkalophilic Corynebacterium sp. which produces NAD(P)-dependent maltose dehydrogenase and glucose dehydrogenase
Agric. Biol. Chem.
44
41-47
1980
Corynebacterium sp., Corynebacterium sp. No. 93-1
-
brenda
Anderson, R.L.; Dahms, A.S.
D-Aldohexose dehydrogenase
Methods Enzymol.
41
147-150
1975
Pseudomonas sp., Pseudomonas sp. MSU-1
brenda
Lin, S.S.; Miyawaki, O.; Nakamura, K.
Continuous production of L-carnitine with NADH regeneration by a nanofiltration membrane reactor with coimmobilized L-carnitine dehydrogenase and glucose dehydrogenase
J. Biosci. Bioeng.
87
361-364
1999
Pseudomonas putida, Pseudomonas putida IAM 12014
brenda
Giardina, P.; DeBasia, M.G.; DeRosa, M.; Gambacort, A.; Buonocore, V.
Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus
Biochem. J.
239
517-522
1986
Saccharolobus solfataricus, Saccharolobus solfataricus MT-4 / DSM 5833
brenda
Manjon, A.; Obon, J.M.; Casanova, P.; Fernandez, V.M.; Ilborra1, J.L.
Increased activity of glucose dehydrogenase co-immobilized with a redox mediator in a bioreactor with electrochemical NAD+ regeneration
Biotechnol. Lett.
24
1227-1232
2002
Komagataeibacter xylinus
-
brenda
Vazquez-Figueroa, E.; Yeh, V.; Broering, J.; Chaparro-Riggers, J.; Bommarius, A.
Thermostable variants constructed via the structure-guided consensus method also show increased stability in salts solutions and homogeneous aqueous-organic media
Protein Eng. Des. Sel.
21
673-680
2008
Bacillus subtilis, Bacillus subtilis 168
brenda
Zhang, X.; Rao, Z.; Zhang, L.; Xu, M.; Yang, T.
Efficient 9alpha-hydroxy-4-androstene-3,17-dione production by engineered Bacillus subtilis co-expressing Mycobacterium neoaurum 3-ketosteroid 9alpha-hydroxylase and B. subtilis glucose 1-dehydrogenase with NADH regeneration
SpringerPlus
5
1207
2016
Bacillus subtilis, Bacillus subtilis 168
brenda
Hu, D.; Wen, Z.; Li, C.; Hu, B.; Zhang, T.; Li, J.; Wu, M.
Characterization of a robust glucose 1-dehydrogenase, SyGDH, and its application in NADPH regeneration for the asymmetric reduction of haloketone by a carbonyl reductase in organic solvent/buffer system
Proc. Biochem.
89
55-62
2020
synthetic construct (AHI17928.1)
-
brenda