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Information on EC 1.1.1.112 - indanol dehydrogenase
for references in articles please use BRENDA:EC1.1.1.112
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.112 indanol dehydrogenase
IUBMB Comments
3(20)α-Hydroxysteroids are also oxidized, more slowly.
The enzyme appears in viruses and cellular organisms
showSynonyms
indanol dehydrogenase, more
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REACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+
A-stereospecific enzyme, ping-pong mechanism
-
indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
indan-1-ol:NAD(P)+ 1-oxidoreductase
3(20)alpha-Hydroxysteroids are also oxidized, more slowly.
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CAS REGISTRY NUMBER
COMMENTARY
37250-43-4
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-tetralol + NAD(P)+
1-tetralone + NAD(P)H
-
Substrates: 195% activity compared to indan-(RS)-1-ol
Products: -
Products: -
?
19-nortestosterone + NAD(P)+
estr-4-en-3,17-dione + NADH
-
Substrates: isoenzymes 3-5
Products: -
Products: -
?
2,3-butanedione + NAD(P)H
2,3-butanediol + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
2,3-heptanedione + NAD(P)H
2,3-heptanediol + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
2-nitrobenzaldehyde + NAD(P)H
2-nitrobenzyl alcohol + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
3-nitrobenzaldehyde + NAD(P)H
3-nitrobenzyl alcohol + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
4-benzoylpyridine + NADH
4-(benzyl alcohol)pyridine + NAD+
-
Substrates: isoenzymes 1,2,3,5,6
Products: -
Products: -
?
4-nitroacetophenone + NADH
(1-hydroxyethyl)-4-nitro-benzene + NAD+
-
Substrates: isoenzymes 1,2,3,5
Products: -
Products: -
?
5alpha-androstan-3-beta,17beta-diol + NAD+
5alpha-androstan-3beta-ol-17-one + NADH
-
Substrates: isoenzymes 2-6
Products: -
Products: -
?
5alpha-androstan-3alpha,17beta-diol + NAD+
5alpha-androstan-3alpha-ol-17-one + NADH
-
Substrates: isoenzymes 1-6
Products: -
Products: -
?
5alpha-androstan-3alpha-ol-17-one + NAD+
5alpha-androstan-3,17-dione + NADH + H+
-
Substrates: isoenzymes 4-5
Products: -
Products: -
?
5alpha-androstan-3alpha-ol-17-one + NADH
5alpha-androstan-3alpha,17alpha-diol + NAD+
-
Substrates: isoenzymes 2,3,4,6
Products: -
Products: -
?
5alpha-androstan-3beta-ol-17-one + NAD+
5alpha-androstan-3,17-dione + NADH + H+
-
Substrates: isoenzymes 2-3
Products: -
Products: -
?
5alpha-androstane-3,17-dione + NAD(P)H
5alpha-androstane-3alpha-ol-17-one + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
5alpha-dihydrotestosterone + NAD(P)+
5alpha-dihydro-17-oxo-testosterone + NADH
-
Substrates: isoenzymes 2-6
Products: -
Products: -
?
5alpha-dihydrotestosterone + NAD+
5alpha-17-oxo-dihydrotestosterone + NADH + H+
-
Substrates: isoenzymes 1-6
Products: -
Products: -
?
5beta-androstan-3alpha,17beta-diol + NAD+
5beta-androstan-3alpha-ol-17-one + NADH
-
Substrates: isoenzymes 1-7
Products: -
Products: -
?
5beta-androstan-3alpha-ol-17-one + NAD+
5beta-androstan-3,17-dione + NADH
-
Substrates: isoenzymes 3-4
Products: -
Products: -
?
5beta-androstan-3alpha-ol-17-one + NADH
5beta-androstan-3alpha,17alpha-diol + NAD+
-
Substrates: isoenzymes 2,3,4,6,7
Products: -
Products: -
?
5beta-androstan-3beta,17beta-diol + NAD+
5alpha-androstan-3beta-ol-17-one + NADH
-
Substrates: isoenzymes 2-6
Products: -
Products: -
?
5beta-androstan-3beta-ol-17-one + NAD+
5beta-androstan-3,17-dione + NADH
-
Substrates: isoenzyme 5
Products: -
Products: -
?
5beta-androstane-3,17-dione + NAD(P)H
5beta-androstane-3alpha-ol-17-one + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
5beta-dihydrotestosterone + NAD(P)+
5beta-dihydro-17-oxo-testosterone + NADH
-
Substrates: isoenzymes 2-6
Products: -
Products: -
?
5beta-dihydrotestosterone + NAD+
5beta-17-oxo-dihydrotestosterone + NADH + H+
-
Substrates: isoenzymes 1-6
Products: -
Products: -
?
5beta-pregnan-3-alpha,20-alpha-diol + NAD(P)+
5beta-pregnan-3,20-dione + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
5beta-pregnan-3-alpha-ol-20-one + NAD(P)+
5beta-pregnan-3,20-dione + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
5beta-pregnane-3,20-dione + 2 NAD(P)H + 2 H+
5beta-pregnan-3alpha,20-alpha-diol + 2 NAD(P)+
-
Substrates: -
Products: -
Products: -
?
5beta-pregnane-3alpha-ol-20-one + NAD(P)H + H+
5beta-pregnan-3alpha,20-alpha-diol + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
5beta-pregnane-3beta-ol-20-one + NAD(P)H + H+
5beta-pregnan-3,20-diol + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
9-fluorenol + NAD(P)+
9-fluorenone + NAD(P)H
-
Substrates: 112% activity compared to indan-(RS)-1-ol
Products: -
Products: -
?
benzosuberol + NAD(P)+
benzosuberone + NAD(P)H
-
Substrates: 12% activity compared to indan-(RS)-1-ol
Products: -
Products: -
?
camphorquinone + NAD(P)H + H+
camphane-2,3-diol + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
chenodeoxycholic acid + NAD(P)+
7alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
cyclohexanol + NAD(P)+
cyclohexanone + NAD(P)H
-
Substrates: isoenzymes 1-7
Products: -
Products: -
?
cyclohexen-3-ol + NAD(P)+
cyclohexen-3-one + NAD(P)H
-
Substrates: 103% activity compared to indan-(RS)-1-ol
Products: -
Products: -
?
dehydrocholic acid + NAD(P)H
cholic acid + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
DL-glyceraldehyde + NADH
glycerol + NAD+
-
Substrates: isoenzymes 1-6
Products: -
Products: -
?
glycochenodeoxycholic acid + NAD(P)+
N[7alpha-hydroxy-3-oxo-5beta-cholan-24-oyl]glycine + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
glycolithocholic acid + NAD(P)+
N[3-oxo-5beta-cholan-24-oyl]glycine + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
lithocholic acid + NAD(P)+
3-oxo-5beta-cholan-24-oic acid + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
progesterone + NAD(P)H
3alpha-hydroxy-4-pregnen-20-one + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
pyridine-4-aldehyde + NADH
pyridine-4-alcohol + NAD+
-
Substrates: isoenzymes 1-7
Products: -
Products: -
?
taurolithocholic acid + NAD(P)+
2[[7alpha,12alpha-dihydroxy-3,24-dioxo-5beta-cholan-24-yl]amino]ethanesulfonic acid + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
testosterone + NAD(P)+
androst-4-ene-3,17-dione + NADH + H+
-
Substrates: -
Products: isoenzymes 3-6
Products: isoenzymes 3-6
?
trans-1,2-dihydroxy-1,2-dihydronaphthalene + NAD(P)+
1,2-naphthoquinone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
trans-acenaphthene-1,2-diol + NAD(P)+
acenaphtene-1,2-dione + NAD(P)H
-
Substrates: 100% activity compared to indan-(RS)-1-ol
Products: -
Products: -
?
1,2,3,4-tetrahydro-1-naphthol + NAD(P)+
1,2,3,4-tetrahydro-1-naphthone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
1,2,3,4-tetrahydro-1-naphthol + NAD(P)+
1,2,3,4-tetrahydro-1-naphthone + NAD(P)H
-
Substrates: isoenzymes 1-7
Products: -
Products: -
?
1-acenaphthenol + NAD(P)+
1-acenaphthenone + NAD(P)H
-
Substrates: 195% activity compared to indan-(RS)-1-ol
Products: -
Products: -
?
1-acenaphthenol + NAD(P)+
1-acenaphthenone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
1-acenaphthenol + NAD(P)+
1-acenaphthenone + NAD(P)H
-
Substrates: isoenzymes 1-7
Products: -
Products: -
?
1-acenaphthenol + NAD(P)+
1-acenaphthenone + NAD(P)H
-
Substrates: four times higher activity compared to indan-1-ol
Products: -
Products: -
?
4-nitrobenzaldehyde + NAD(P)H
4-nitrobenzyl alcohol + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
4-nitrobenzaldehyde + NAD(P)H
4-nitrobenzyl alcohol + NAD(P)+
-
Substrates: isoenzymes 1-7
Products: -
Products: -
?
benzene dihydrodiol + NAD(P)+
o-benzoquinone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
benzene dihydrodiol + NAD(P)+
o-benzoquinone + NAD(P)H
-
Substrates: isoenzymes 1-7
Products: -
Products: -
?
cyclohex-2-en-1-ol + NAD(P)+
cyclohex-2-en-1-one + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
cyclohex-2-en-1-ol + NAD(P)+
cyclohex-2-en-1-one + NAD(P)H
-
Substrates: isoenzymes 1-7
Products: -
Products: -
?
indan-(RS)-1-ol + NAD(P)+
indan-1-one + NAD(P)H
-
Substrates: -
Products: 100% activity
Products: 100% activity
?
indan-(S)-1-ol + NAD(P)+
indan-1-one + NAD(P)H
-
Substrates: 171% activity compared to indan-(RS)-1-ol
Products: -
Products: -
?
indan-(S)-1-ol + NAD(P)+
indan-1-one + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
indan-(S)-1-ol + NAD(P)+
indan-1-one + NAD(P)H
-
Substrates: isoenzymes 1-7
Products: -
Products: -
?
indan-2-ol + NAD(P)+
indan-2-one + NAD(P)H
-
Substrates: isoenzymes 1,2,3,4,6
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
6alpha-Methylprednisolone
-
0.1 mM, oxidation of acenaphthenol: 0% inhibition of isozyme 1, 40% inhibition of isozyme 2, 23%,inhibition of isozyme 3, 89% inhibition of isozyme 4, 14% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 18% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 7% inhibition of isozyme 1, 41% inhibition of isozyme 2, 30%,inhibition of isozyme 3, 86% inhibition of isozyme 4, 11% inhibition of isozyme 5, 16% inhibition of isozyme 6 and 20% inhibition of isoenzyme 7
betamethazone
-
0.05 mM, oxidation of acenaphthenol: 32% inhibition of isozyme 1, 16% inhibition of isozyme 2, 90%,inhibition of isozyme 3, 95% inhibition of isozyme 4, 27% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 14% inhibition of isozyme 1, 26% inhibition of isozyme 2, 97%,inhibition of isozyme 3, 96% inhibition of isozyme 4, 30% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 6% inhibition of isoenzyme 7
Dienstrol
-
0.01 mM, oxidation of acenaphthenol: 27% inhibition of isozyme 1, 84% inhibition of isozyme 2, 99%,inhibition of isozyme 3, 94% inhibition of isozyme 4, 0% inhibition of isozyme 5, 66% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 27% inhibition of isozyme 1, 85% inhibition of isozyme 2, 99%,inhibition of isozyme 3, 97% inhibition of isozyme 4, 0% inhibition of isozyme 5, 51% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7
diethylstilbestrol
-
0.01 mM, oxidation of acenaphthenol: 25% inhibition of isozyme 1, 68% inhibition of isozyme 2, 94%,inhibition of isozyme 3, 90% inhibition of isozyme 4, 6% inhibition of isozyme 5, 44% inhibition of isozyme 6 and 44% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 23% inhibition of isozyme 1, 69% inhibition of isozyme 2, 87%,inhibition of isozyme 3, 99% inhibition of isozyme 4, 0% inhibition of isozyme 5, 49% inhibition of isozyme 6 and 47% inhibition of isoenzyme 7
Flufenamic acid
-
0.1 mM, oxidation of acenaphthenol: 54% inhibition of isozyme 1, 47% inhibition of isozyme 2, 64%,inhibition of isozyme 3, 60% inhibition of isozyme 4, 50% inhibition of isozyme 5, 57% inhibition of isozyme 6 and 38% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 46% inhibition of isozyme 1, 45% inhibition of isozyme 2, 47%,inhibition of isozyme 3, 49% inhibition of isozyme 4, 58% inhibition of isozyme 5, 46% inhibition of isozyme 6 and 43% inhibition of isoenzyme 7
indomethacin
-
0.1 mM, oxidation of acenaphthenol: 20% inhibition of isozyme 1, 49% inhibition of isozyme 2, 55%,inhibition of isozyme 3, 78% inhibition of isozyme 4, 64% inhibition of isozyme 5, 59% inhibition of isozyme 6 and 3% inhibition of isoenzyme 7
Zomepirac
-
0.1 mM, oxidation of acenaphthenol: 69% inhibition of isozyme 1, 46% inhibition of isozyme 2, 71%,inhibition of isozyme 3, 78% inhibition of isozyme 4, 69% inhibition of isozyme 5, 72% inhibition of isozyme 6 and 56% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 70% inhibition of isozyme 1, 68% inhibition of isozyme 2, 68%,inhibition of isozyme 3, 56% inhibition of isozyme 4, 68% inhibition of isozyme 5, 71% inhibition of isozyme 6 and 66% inhibition of isoenzyme 7
Hexestrol
-
0.01 mM, oxidation of acenaphthenol: 76% inhibition of isozyme 1, 82% inhibition of isozyme 2, 95%,inhibition of isozyme 3, 87% inhibition of isozyme 4, 20% inhibition of isozyme 5, 50% inhibition of isozyme 6 and 72% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 66% inhibition of isozyme 1, 84% inhibition of isozyme 2, 90%,inhibition of isozyme 3, 85% inhibition of isozyme 4, 10% inhibition of isozyme 5, 50% inhibition of isozyme 6 and 77% inhibition of isoenzyme 7
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). AK1C1_HUMAN
323
0
36788
Swiss-Prot
other Location (Reliability: 2)
AK1C1_MACFA
323
0
36947
Swiss-Prot
other Location (Reliability: 2)
AK1C1_MACFU
323
0
36963
Swiss-Prot
other Location (Reliability: 2)
AK1C1_PONAB
323
0
36932
Swiss-Prot
other Location (Reliability: 2)
AK1C2_HUMAN
323
0
36735
Swiss-Prot
other Location (Reliability: 2)
M9PI17_DROME
316
0
35895
TrEMBL
other Location (Reliability: 2)
Q7PLK6_DROME
366
0
42580
TrEMBL
other Location (Reliability: 1)
A0A084G895_PSEDA
318
0
35111
TrEMBL
Mitochondrion (Reliability: 3)
Q9VTK9_DROME
316
0
35922
TrEMBL
other Location (Reliability: 2)
M9PF61_DROME
350
0
40137
TrEMBL
Mitochondrion (Reliability: 3)
Q8IQF8_DROME
350
0
40110
TrEMBL
Mitochondrion (Reliability: 3)
D2A6K3_DROME
384
0
44540
TrEMBL
other Location (Reliability: 2)
AK1C3_HUMAN
323
0
36853
Swiss-Prot
other Location (Reliability: 5)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
31000
36000