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BRENDA support

Information on EC 1.1.1.110 - aromatic 2-oxoacid reductase

for references in articles please use BRENDA:EC1.1.1.110

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IUBMB Comments

The enzymes from anaerobic bacteria such as Clostridium sporogenes participate in the fermentation pathways of L-phenylalanine, L-tyrosine and L-tryptophan. The enzyme from the yeast Candida maltosa has similar activity, but, unlike the bacterial enzyme, requires Mn2+ and can also use NADPH with lower activity.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
(indol-3-yl)lactate:NAD+ oxidoreductase, (R)-aromatic lactate dehydrogenase, D-aryllactate D-hydrogenase, EC 1.1.1.222, indolelactate dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-(indol-3-yl)lactate + NAD+ = (indol-3-yl)pyruvate + NADH + H+
show the reaction diagram
(3)
-
-
-
(R)-3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
4-hydroxybenzoate biosynthesis I (eukaryotes), L-phenylalanine degradation IV (mammalian, via side chain), L-phenylalanine degradation VI (reductive Stickland reaction), L-tryptophan degradation IV (via indole-3-lactate), L-tryptophan degradation XIII (reductive Stickland reaction), L-tyrosine degradation V (reductive Stickland reaction), tropane alkaloids biosynthesis
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