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EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.2 With a cytochrome as acceptor

1.2.3 With oxygen as acceptor

1.2.4 With a disulfide as acceptor

1.2.5 With a quinone or similar compound as acceptor

1.2.7 With an iron-sulfur protein as acceptor

1.2.98 With other, known, physiological acceptors

1.2.99 With unknown physiological acceptors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

6.1 Forming carbon-oxygen bonds

6.2 Forming carbon-sulfur bonds

6.2.1 Acid-thiol ligases

6.2.1.1 acetate—CoA ligase

6.2.1.2 medium-chain acyl-CoA ligase

6.2.1.3 long-chain-fatty-acid—CoA ligase

6.2.1.4 succinate—CoA ligase (GDP-forming)

6.2.1.5 succinate—CoA ligase (ADP-forming)

6.2.1.6 glutarate—CoA ligase

6.2.1.7 cholate—CoA ligase

6.2.1.8 oxalate—CoA ligase

6.2.1.9 malate—CoA ligase

6.2.1.10 carboxylic acid—CoA ligase (GDP-forming)

6.2.1.11 biotin—CoA ligase

6.2.1.12 4-coumarate—CoA ligase

6.2.1.13 acetate—CoA ligase (ADP-forming)

6.2.1.14 6-carboxyhexanoate—CoA ligase

6.2.1.15 arachidonate—CoA ligase

6.2.1.16 acetoacetate—CoA ligase

6.2.1.17 propionate—CoA ligase

6.2.1.18 citrate—CoA ligase

6.2.1.19 long-chain-fatty-acid—protein ligase

6.2.1.20 long-chain-fatty-acid—[acyl-carrier-protein] ligase

6.2.1.21 created 1986, deleted 2001

6.2.1.22 [citrate (pro-3S)-lyase] ligase

6.2.1.23 dicarboxylate—CoA ligase

6.2.1.24 phytanate—CoA ligase

6.2.1.25 benzoate—CoA ligase

6.2.1.26 o-succinylbenzoate—CoA ligase

6.2.1.27 4-hydroxybenzoate—CoA ligase

6.2.1.28 3α,7α-dihydroxy-5β-cholestanate—CoA ligase

6.2.1.29 (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate—CoA ligase

6.2.1.30 phenylacetate—CoA ligase

6.2.1.31 2-furoate—CoA ligase

6.2.1.32 anthranilate—CoA ligase

6.2.1.33 4-chlorobenzoate—CoA ligase

6.2.1.34 trans-feruloyl-CoA synthase

6.2.1.35 acetate—[acyl-carrier protein] ligase

6.2.1.36 3-hydroxypropionyl-CoA synthase

6.2.1.37 3-hydroxybenzoate—CoA ligase

6.2.1.38 (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase

6.2.1.39 [butirosin acyl-carrier protein]—L-glutamate ligase

6.2.1.40 4-hydroxybutyrate—CoA ligase (AMP-forming)

6.2.1.41 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate—CoA ligase

6.2.1.42 3-oxocholest-4-en-26-oate—CoA ligase

6.2.1.43 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase

6.2.1.44 3-(methylthio)propionyl—CoA ligase

6.2.1.45 E1 ubiquitin-activating enzyme

6.2.1.46 L-allo-isoleucine—holo-[CmaA peptidyl-carrier protein] ligase

6.2.1.47 medium-chain-fatty-acid—[acyl-carrier-protein] ligase

6.2.1.48 carnitine—CoA ligase

6.2.1.49 long-chain fatty acid adenylyltransferase FadD28

6.2.1.50 4-hydroxybenzoate adenylyltransferase FadD22

6.2.1.51 4-hydroxyphenylalkanoate adenylyltransferase FadD29

6.2.1.52 L-firefly luciferin—CoA ligase

6.2.1.53 L-proline—[L-prolyl-carrier protein] ligase

6.2.1.54 D-alanine—[D-alanyl-carrier protein] ligase

6.2.1.55 E1 SAMP-activating enzyme

6.2.1.56 4-hydroxybutyrate—CoA ligase (ADP-forming)

6.2.1.57 long-chain fatty acid adenylase/transferase FadD23

6.2.1.58 isophthalate—CoA ligase

6.2.1.59 long-chain fatty acid adenylase/transferase FadD26

6.2.1.60 marinolic acid—CoA ligase

6.2.1.61 salicylate—[aryl-carrier protein] ligase

6.2.1.62 3,4-dihydroxybenzoate—[aryl-carrier protein] ligase

6.2.1.63 L-arginine—[L-arginyl-carrier protein] ligase

6.2.1.64 E1 NEDD8-activating enzyme

6.2.1.65 salicylate—CoA ligase

6.2.1.66 glyine—[glycyl-carrier protein] ligase

6.2.1.67 L-alanine—[L-alanyl-carrier protein] ligase

6.2.1.68 L-glutamate—[L-glutamyl-carrier protein] ligase

6.2.1.69 L-cysteine—[L-cysteinyl-carrier protein] ligase

6.2.1.70 L-threonine—[L-threonyl-carrier protein] ligase

6.2.1.71 2,3-dihydroxybenzoate—[aryl-carrier protein] ligase

6.2.1.72 L-serine—[L-seryl-carrier protein] ligase

6.2.1.73 L-tryptophan—[L-tryptophyl-carrier protein] ligase

6.2.1.74 3-amino-5-hydroxybenzoate—[acyl-carrier protein] ligase

6.2.1.75 indoleacetate—CoA ligase

6.2.1.76 malonate—CoA ligase

6.2.2 Amide---thiol ligases

6.3 Forming carbon-nitrogen bonds

6.4 Forming carbon-carbon bonds

6.5 Forming phosphoric-ester bonds

6.6 Forming nitrogen—metal bonds

6.7 Forming nitrogen-nitrogen bonds

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Release 2023.1 (January 2023)