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EC Details
EC number
Accepted name
pyruvate dehydrogenase (quinone)
pyruvate + ubiquinone + H2O = acetate + CO2 + ubiquinol
Other name(s)
pyruvate dehydrogenase (ambiguous), pyruvic dehydrogenase (ambiguous), pyruvic (cytochrome b1) dehydrogenase (incorrect), pyruvate:ubiquinone-8-oxidoreductase, pyruvate oxidase (ambiguous), pyruvate dehydrogenase (cytochrome) (incorrect)
Systematic name
pyruvate:ubiquinone oxidoreductase
Flavoprotein (FAD) [1]. This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone [2,3]. Does not accept menaquinone. Activity is greatly enhanced by lipids [4,5,6]. Requires thiamine diphosphate [7]. The enzyme can also form acetoin [8].
created 2010
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