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EC 1.14.21.12 Details
EC number
1.14.21.12
Accepted name
(S)-nandinine synthase
Reaction
(S)-scoulerine + NADPH + H+ + O2 = (S)-nandinine + NADP+ + 2 H2O
Other name(s)
CYP719A3
Systematic name
(S)-scoulerine,NADPH:oxygen oxidoreductase [(S)-nandinine-forming]
Comment
A cytochrome P-450 heme-thiolate enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid (S)-nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-scoulerine. cf. EC 1.14.21.2, (S)-cheilanthifoline synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-cheilanthifoline.
History
created 2016, deleted 2018
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