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EC 1.14.19.77 Details
show Brenda entryEC number
1.14.19.77
Accepted name
plasmanylethanolamine desaturase
Reaction
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O
Other name(s)
TMEM189 (gene name),
2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase,
alkylacylglycerophosphoethanolamine desaturase,
alkylacylglycero-phosphorylethanolamine dehydrogenase,
alkyl-acylglycerophosphorylethanolamine dehydrogenase,
1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase,
1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase
Systematic name
plasmanylethanolamine,ferrocytochrome b5:oxygen oxidoreductase (plasmenylethanolamine-forming)
Comment
The enzyme catalyses the introduction of a double bond at position 1 of the alkyl group attached by an ether bond at the sn-1 position of plasmanylethanolamine, generating a vinyl ether-containing plasmenylethanolamine. The enzyme is found in animals and some bacteria, but not in plants, fungi, or most aerobic bacteria.
History
created 1976 as EC 1.14.99.19, transferred 2020 to EC 1.14.19.77
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.99.1 D-amino-acid dehydrogenase
