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EC 1.14.19.49 Details
EC number
1.14.19.49
Accepted name
tetracycline 7-halogenase
Reaction
tetracycline + FADH2 + chloride + O2 + H+ = 7-chlorotetracycline + FAD + 2 H2O
Other name(s)
ctcP (gene name)
Systematic name
tetracycline:FADH2 oxidoreductase (7-halogenating)
Comment
The enzyme, characterized from the bacterium Streptomyces aureofaciens, is a member of the flavin-dependent halogenase family. The enzyme forms a lysine chloramine intermediate on an internal lysine residue before transferring the chlorine to the substrate. It is stereo-selective for the 4S (natural) isomer of tetracycline. FADH2 is provided by a dedicated EC 1.5.1.36, flavin reductase (NADH).
History
created 2016
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