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EC 1.14.19.22 Details
EC number
1.14.19.22
Accepted name
acyl-lipid ω-6 desaturase (cytochrome b5)
Reaction
an oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
Other name(s)
oleate desaturase (ambiguous), linoleate synthase (ambiguous), oleoyl-CoA desaturase (incorrect), oleoylphosphatidylcholine desaturase (ambiguous), phosphatidylcholine desaturase (ambiguous), n-6 desaturase (ambiguous), FAD2 (gene name)
Systematic name
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,ferrocytochrome-b5:oxygen oxidoreductase (12,13 cis-dehydrogenating)
CAS registry number
72536-70-0
Comment
This microsomal enzyme introduces a cis double bond in fatty acids attached to lipid molecules at a location 6 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. The most common substrates are oleoyl groups attached to either the sn-1 or sn-2 position of the glycerol backbone in phosphatidylcholine. cf. EC 1.14.19.23, acyl-lipid ω-6 desaturase (ferredoxin).
History
created 1984 as EC 1.3.1.35, transferred 2015 to EC 1.14.19.22
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