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EC 1.14.19.5 Details
EC number
1.14.19.5
Accepted name
acyl-CoA 11-(Z)-desaturase
Reaction
an acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11Z)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
Other name(s)
Δ11 desaturase, fatty acid Δ11-desaturase, TpDESN, Cro-PG, Δ11 fatty acid desaturase, Z/E11-desaturase, Δ11-palmitoyl-CoA desaturase, acyl-CoA,hydrogen donor:oxygen Δ11-oxidoreductase, Δ11-fatty-acid desaturase
Systematic name
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (11,12 cis-dehydrogenating)
Comment
The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs. In moths the enzyme participates in the biosynthesis of their sex pheromones. The enzyme from the marine microalga Thalassiosira pseudonana is specific for palmitoyl-CoA (16:0) [4], that from the leafroller moth Choristoneura rosaceana desaturates myristoyl-CoA (14:0) [5], while that from the moth Spodoptera littoralis accepts both substrates [1]. The enzyme contains three histidine boxes that are conserved in all desaturases [2]. It is membrane-bound, and contains a cytochrome b5-like domain at the N-terminus that serves as the electron donor for the active site of the desaturase.
History
created 2008 (EC 1.14.99.32 created 2000, incorporated 2015), modified 2015
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