EC Explorer

1.14.19.54

1,2-dehydroreticuline synthase

(S)-reticuline + [reduced NADPH—hemoprotein reductase] + O₂ = 1,2-dehydroreticuline + [oxidized NADPH—hemoprotein reductase] + 2 H₂O

STORR, CYP82Y2 (gene name), DRS (gene name)

(S)-reticuline,[reduced NADPH—hemoprotein reductase]:oxygen 1,2-oxidoreductase

A P-450 (heme-thiolate) cytochrome. The enzyme from Papaver rhoeas (field poppy) is specific for (S)-reticuline and does not act on the (R)-form. The enzyme from Papaver somniferum (opium poppy), which is involved in the biosynthesis of morphine and related alkaloids, forms a fusion protein with EC 1.5.1.27, 1,2-dehydroreticulinium reductase (NADPH), which catalyses the reduction of 1,2-dehydroreticuline to (R)-reticuline, thus forming an epimerase system that converts (S)-reticuline to (R)-reticuline.

created 2018