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EC 1.14.19.7 Details
show Brenda entryEC number
1.14.19.7
Accepted name
(S)-2-hydroxypropylphosphonic acid epoxidase
Reaction
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2 = (1R,2S)-epoxypropylphosphonate + NAD+ + 2 H2O
Other name(s)
HPP epoxidase,
HppE,
2-hydroxypropylphosphonic acid epoxidase,
Fom4,
(S)-2-hydroxypropylphosphonate epoxidase
Systematic name
(S)-2-hydroxypropylphosphonate,NADH:oxygen epoxidase
Comment
Contains one non-heme iron centre per monomer [1,5]. FMN is required to mediate the transfer of reducing equivalents from NADH to the active site iron [1]. This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species.
History
created 2011, deleted 2014
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.19.1 stearoyl-CoA 9-desaturase
