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EC 1.14.99.3 Details
EC number
1.14.99.3
Accepted name
heme oxygenase (biliverdin-producing)
Reaction
protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O
Other name(s)
ORP33 proteins, haem oxygenase (ambiguous), heme oxygenase (decyclizing) (ambiguous), heme oxidase (ambiguous), haem oxidase (ambiguous), heme oxygenase (ambiguous), heme,hydrogen-donor:oxygen oxidoreductase (α-methene-oxidizing, hydroxylating)
Systematic name
protoheme,hydrogen-donor:oxygen oxidoreductase (α-methene-oxidizing, hydroxylating)
CAS registry number
9059-22-7
Comment
Requires NAD(P)H and EC 1.6.2.4, NADPH—hemoprotein reductase. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the α-carbon to CO. The central iron is kept in the reduced state by NAD(P)H.
History
created 1972, modified 2006, deleted 2015
EC Tree
1.14.99.5 created 1972, modified 1986, modified 2000, deleted 2000
1.14.99.6 created 1972, modified 2000, deleted 2000
1.14.99.8 created 1972, deleted 1984
1.14.99.13 created 1972, deleted 1984
1.14.99.16 created 1972, deleted 2002
1.14.99.17 created 1972, deleted 1976
1.14.99.18 created 1976, modified 1999, deleted 2003
1.14.99.25 created 1986, deleted 2000