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EC 1.14.15.16 Details
EC number
1.14.15.16
Accepted name
vitamin D3 24-hydroxylase
Reaction
(1) calcitriol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitetrol + 2 oxidized adrenodoxin + H2O;;(2) calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = secalciferol + 2 oxidized adrenodoxin + H2O
Other name(s)
CYP24A1
Systematic name
calcitriol,adrenodoxin:oxygen oxidoreductase (24-hydroxylating)
Comment
This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase.
History
created 2011 as EC 1.14.13.126, transferred 2016 to EC 1.14.15.16
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