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EC 1.4.3.22 Details
EC number
1.4.3.22
Accepted name
diamine oxidase
Reaction
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
Other name(s)
amine oxidase (ambiguous), amine oxidase (copper-containing) (ambiguous), CAO (ambiguous), Cu-containing amine oxidase (ambiguous), copper amine oxidase (ambiguous), diamine oxidase (ambiguous), diamino oxhydrase (ambiguous), histaminase, histamine deaminase (incorrect), semicarbazide-sensitive amine oxidase (incorrect), SSAO (incorrect)
Systematic name
histamine:oxygen oxidoreductase (deaminating)
Comment
A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 (primary-amine oxidase) but unlike EC 1.4.3.4 (monoamine oxidase), they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
History
created 2007 (EC 1.4.3.6 created 1961, part-incorporated 2008)
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EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2 Acting on the aldehyde or oxo group of donors
1.3 Acting on the CH-CH group of donors
1.4 Acting on the CH-NH2 group of donors
1.4.1 With NAD+ or NADP+ as acceptor
1.4.2 With a cytochrome as acceptor
1.4.3 With oxygen as acceptor
1.4.3.1 D-aspartate oxidase
1.4.3.2 L-amino-acid oxidase
1.4.3.3 D-amino-acid oxidase
1.4.3.4 monoamine oxidase
1.4.3.5 pyridoxal 5′-phosphate synthase
1.4.3.6 amine oxidase (copper-containing)
1.4.3.7 D-glutamate oxidase
1.4.3.8 ethanolamine oxidase
1.4.3.9 created 1972, deleted 1984
1.4.3.10 putrescine oxidase
1.4.3.11 L-glutamate oxidase
1.4.3.12 cyclohexylamine oxidase
1.4.3.13 protein-lysine 6-oxidase
1.4.3.14 L-lysine oxidase
1.4.3.15 D-glutamate(D-aspartate) oxidase
1.4.3.16 L-aspartate oxidase
1.4.3.17 created 2000, deleted 2003
1.4.3.18 proposed 2000
1.4.3.19 glycine oxidase
1.4.3.20 L-lysine 6-oxidase
1.4.3.21 primary-amine oxidase
1.4.3.22 diamine oxidase
1.4.3.23 7-chloro-L-tryptophan oxidase
1.4.3.24 pseudooxynicotine oxidase
1.4.3.25 L-arginine oxidase
1.4.3.26 pre-mycofactocin synthase
1.4.4 With a disulfide as acceptor
1.4.5 With a quinone or other compound as acceptor
1.4.7 With an iron-sulfur protein as acceptor
1.4.9 With a copper protein as acceptor
1.4.98. undefined
1.4.99 With unknown physiological acceptors
1.5 Acting on the CH-NH group of donors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.15 Acting on superoxide as acceptor
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.97 Other oxidoreductases
1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses
1.98 Enzymes using H2 as reductant (deleted subclass)
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
7 Translocases
7.1 Catalysing the translocation of hydrons
7.2 Catalysing the translocation of inorganic cations
7.3 Catalysing the translocation of inorganic anions and their chelates
7.4 Catalysing the translocation of amino acids and peptides
7.5 Catalysing the translocation of carbohydrates and their derivatives
7.6 Catalysing the translocation of other compounds