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EC 1.4.1.14 Details
EC number
1.4.1.14
Accepted name
glutamate synthase (NADH)
Reaction
2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+;;(1a) L-glutamate + NH3 = L-glutamine + H2O;;(1b) L-glutamate + NAD+ + H2O = NH3 + 2-oxoglutarate + NADH + H+
Other name(s)
glutamate (reduced nicotinamide adenine dinucleotide) synthase, NADH: GOGAT, L-glutamate synthase (NADH), L-glutamate synthetase, NADH-glutamate synthase, NADH-dependent glutamate synthase
Systematic name
L-glutamate:NAD+ oxidoreductase (transaminating)
CAS registry number
65589-88-0
Comment
A flavoprotein (FMN). The reaction takes place in the direction of L-glutamate production. The protein is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.2, glutamate dehydrogenase).
History
created 1978, modified 2019
EC Tree
1.4.1.6 created 1961, deleted 1982
1.97.1.5 created 2000 deleted 2001
1.97.1.6 created 2000 deleted 2001
1.97.1.7 created 2000, deleted 2001