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EC 1.4.1.28 Details
show Brenda entryEC number
1.4.1.28
Accepted name
secondary-alkyl amine dehydrogenase [NAD(P)+]
Reaction
a secondary-alkyl amine + H2O + NAD(P)+ = a ketone + NH3 + NAD(P)H + H+
Other name(s)
AmDH (ambiguous),
amine dehydrogenase (ambiguous)
Systematic name
secondary-alkyl amine:NAD(P)+ oxidoreductase (deaminating)
Comment
The enzyme has been shown to react preferentially with short-chain ketones such as cyclohexanone, primary amine groups attached to secondary alkyl groups, or D- and L-amino acids. It also reduces aldehydes to primary amines. Cosubstrate preference depends on the substrate.
History
created 2022
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.1.6 created 1961, deleted 1982 1.4.3.9 created 1972, deleted 1984 1.4.3.17 created 2000, deleted 2003 1.4.3.18 proposed 2000
