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EC 1.4.1.12 Details
EC number
1.4.1.12
Accepted name
2,4-diaminopentanoate dehydrogenase
Reaction
(2R,4S)-2,4-diaminopentanoate + H2O + NAD(P)+ = (2R)-2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+
Other name(s)
2,4-diaminopentanoic acid C4 dehydrogenase
Systematic name
(2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)
CAS registry number
39346-26-4
Comment
Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].
History
created 1976, modified 2017
EC Tree
1.4.1.6 created 1961, deleted 1982