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EC 1.4.1.2 Details

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EC number

1.4.1.2

Accepted name

glutamate dehydrogenase

Reaction

L-glutamate + H₂O + NAD⁺ = 2-oxoglutarate + NH₃ + NADH + H⁺

Other name(s)

glutamic dehydrogenase, glutamate dehydrogenase (NAD), glutamate oxidoreductase, glutamic acid dehydrogenase, L-glutamate dehydrogenase, NAD-dependent glutamate dehydrogenase, NAD-dependent glutamic dehydrogenase, NAD-glutamate dehydrogenase, NAD-linked glutamate dehydrogenase, NAD-linked glutamic dehydrogenase, NAD-specific glutamic dehydrogenase, NAD-specific glutamate dehydrogenase, NAD:glutamate oxidoreductase, NADH-linked glutamate dehydrogenase

Systematic name

L-glutamate:NAD⁺ oxidoreductase (deaminating)

CAS registry number

9001-46-1

History

created 1961

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.1.1 alanine dehydrogenase

1.4.1.2 glutamate dehydrogenase

1.4.1.3 glutamate dehydrogenase [NAD(P)⁺]

1.4.1.4 glutamate dehydrogenase (NADP⁺)

1.4.1.5 L-amino-acid dehydrogenase

1.4.1.6 created 1961, deleted 1982

1.4.1.7 serine 2-dehydrogenase

1.4.1.8 valine dehydrogenase (NADP⁺)

1.4.1.9 leucine dehydrogenase

1.4.1.10 glycine dehydrogenase

1.4.1.11 L-erythro-3,5-diaminohexanoate dehydrogenase

1.4.1.12 2,4-diaminopentanoate dehydrogenase

1.4.1.13 glutamate synthase (NADPH)

1.4.1.14 glutamate synthase (NADH)

1.4.1.15 lysine dehydrogenase

1.4.1.16 diaminopimelate dehydrogenase

1.4.1.17 N-methylalanine dehydrogenase

1.4.1.18 lysine 6-dehydrogenase

1.4.1.19 tryptophan dehydrogenase

1.4.1.20 phenylalanine dehydrogenase

1.4.1.21 aspartate dehydrogenase

1.4.1.22 ornithine cyclodeaminase

1.4.1.23 valine dehydrogenase (NAD⁺)

1.4.1.24 3-dehydroquinate synthase II

1.4.1.25 L-arginine dehydrogenase

1.4.1.26 2,4-diaminopentanoate dehydrogenase (NAD⁺)

1.4.1.27 glycine cleavage system

1.4.1.28 secondary-alkyl amine dehydrogenase [NAD(P)⁺]

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.20.1 With NAD⁺ or NADP⁺ as acceptor

1.20.2 With a cytochrome as acceptor

1.20.4 With disulfide as acceptor

1.20.9 With a copper protein as acceptor

1.20.98 With other, known, physiological acceptors

1.20.99 With unknown physiological acceptors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)