EC 188.8.131.52 Details
L-tyrosine + 2 NADP+ + 2 I- = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ (overall reaction);;(1a) L-tyrosine + NADP+ + I- = 3-iodo-L-tyrosine + NADPH + H+;;(1b) 3-iodo-L-tyrosine + NADP+ + I- = 3,5-diiodo-L-tyrosine + NADPH + H+
iodotyrosine dehalogenase 1, DEHAL1
NADP+:L-tyrosine oxidoreductase (iodinating)
The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.
created 2010, deleted 2015
184.108.40.206 created 1972, modified 1982 (EC 220.127.116.11 created 1961, incorporated 1982), deleted 2003