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EC 1.97.1.11 Details

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EC number

1.97.1.11

Accepted name

thyroxine 5-deiodinase

Reaction

3,3′,5′-triiodo-L-thyronine + iodide + A + H⁺ = L-thyroxine + AH2

Other name(s)

diiodothyronine 5′-deiodinase[ambiguous], iodothyronine 5-deiodinase, iodothyronine inner ring monodeiodinase, type III iodothyronine deiodinase

Systematic name

acceptor:3,3′,5′-triiodo-L-thyronine oxidoreductase (iodinating)

CAS registry number

74506-30-2

Comment

The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.

History

created 2003, deleted 2015

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.22.1 With NAD⁺ or NADP⁺ as acceptor

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.97.1.1 chlorate reductase

1.97.1.2 pyrogallol hydroxytransferase

1.97.1.3 sulfur reductase

1.97.1.4 [formate-C-acetyltransferase]-activating enzyme

1.97.1.5 created 2000 deleted 2001

1.97.1.6 created 2000 deleted 2001

1.97.1.7 created 2000, deleted 2001

1.97.1.8 tetrachloroethene reductive dehalogenase

1.97.1.9 selenate reductase

1.97.1.10 thyroxine 5′-deiodinase

1.97.1.11 thyroxine 5-deiodinase

1.97.1.12 photosystem I

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)