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EC 1.22.1.1 Details
EC number
1.22.1.1
Accepted name
iodotyrosine deiodinase
Reaction
L-tyrosine + 2 NADP+ + 2 I- = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ (overall reaction);;(1a) L-tyrosine + NADP+ + I- = 3-iodo-L-tyrosine + NADPH + H+;;(1b) 3-iodo-L-tyrosine + NADP+ + I- = 3,5-diiodo-L-tyrosine + NADPH + H+
Other name(s)
iodotyrosine dehalogenase 1, DEHAL1
Systematic name
NADP+:L-tyrosine oxidoreductase (iodinating)
Comment
The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.
History
created 2010, deleted 2015
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