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EC 1.3.8.6 Details

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EC number

1.3.8.6

Accepted name

glutaryl-CoA dehydrogenase (ETF)

Reaction

glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO₂ + reduced electron-transfer flavoprotein (overall reaction);;(1a) glutaryl-CoA + electron-transfer flavoprotein = (E)-glutaconyl-CoA + reduced electron-transfer flavoprotein;;(1b) (E)-glutaconyl-CoA = crotonyl-CoA + CO₂

Other name(s)

glutaryl coenzyme A dehydrogenase, glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating), glutaryl-CoA dehydrogenase

Systematic name

glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)

CAS registry number

37255-38-2

Comment

Contains FAD. The enzyme catalyses the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 7.2.4.5, glutaconyl-CoA decarboxylase). FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyses the oxidation to glutaconyl-CoA [EC 1.3.99.32, glutaryl-CoA dehydrogenase (acceptor)].

History

created 1972 as EC 1.3.99.7, transferred 2012 to EC 1.3.8.6, modified 2013, modified 2019

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.2 With a cytochrome as acceptor

1.3.3 With oxygen as acceptor

1.3.4 With a disulfide as acceptor

1.3.5 With a quinone or related compound as acceptor

1.3.7 With an iron-sulfur protein as acceptor

1.3.8 With a flavin as acceptor

1.3.8.1 short-chain acyl-CoA dehydrogenase

1.3.8.2 4,4′-diapophytoene desaturase (4,4′-diapolycopene-forming)

1.3.8.3 (R)-benzylsuccinyl-CoA dehydrogenase

1.3.8.4 isovaleryl-CoA dehydrogenase

1.3.8.5 short-chain 2-methylacyl-CoA dehydrogenase

1.3.8.6 glutaryl-CoA dehydrogenase (ETF)

1.3.8.7 medium-chain acyl-CoA dehydrogenase

1.3.8.8 long-chain acyl-CoA dehydrogenase

1.3.8.9 very-long-chain acyl-CoA dehydrogenase

1.3.8.10 cyclohex-1-ene-1-carbonyl-CoA dehydrogenase

1.3.8.11 cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)

1.3.8.12 (2S)-methylsuccinyl-CoA dehydrogenase

1.3.8.13 crotonobetainyl-CoA reductase

1.3.8.14 L-prolyl-[peptidyl-carrier protein] dehydrogenase

1.3.8.15 3-(aryl)acrylate reductase

1.3.8.16 2-amino-4-deoxychorismate dehydrogenase

1.3.8.17 dehydro coenzyme F₄₂₀ reductase

1.3.98 With other, known, physiological acceptors

1.3.99 With unknown physiological acceptors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.22.1 With NAD⁺ or NADP⁺ as acceptor

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)