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EC 1.3.98.5 Details
EC number
1.3.98.5
Accepted name
hydrogen peroxide-dependent heme synthase
Reaction
Fe-coproporphyrin III + 2 H2O2 = protoheme + 2 CO2 + 4 H2O (overall reaction);;(1a) Fe-coproporphyrin III + H2O2 = harderoheme III + CO2 + 2 H2O;;(1b) harderoheme III + H2O2 = protoheme + CO2 + 2 H2O
Other name(s)
coproheme III oxidative decarboxylase, hemQ (gene name)
Systematic name
Fe-coproporphyrin III:hydrogen peroxide oxidoreductase (decarboxylating)
Comment
The enzyme participates in a heme biosynthesis pathway found in Gram-positive bacteria. The initial decarboxylation step is fast and yields the three-propanoate harderoheme isomer III. The second decarboxylation is much slower. cf. EC 1.3.98.6, SAM-dependent heme synthase.
History
created 2019
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