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EC 1.3.98.4 Details
EC number
1.3.98.4
Accepted name
5a,11a-dehydrotetracycline reductase
Reaction
tetracycline + oxidized coenzyme F420 = 5a,11a-dehydrotetracycline + reduced coenzyme F420
Other name(s)
oxyR (gene name), 12-dehydrotetracycline dehydrogenase, dehydrooxytetracycline dehydrogenase, 12-dehydrotetracycline reductase
Systematic name
tetracycline:coenzyme F420 dehydrogenase
Comment
The enzyme, characterized from the bacteria Streptomyces aureofaciens and Streptomyces rimosus, catalyses the last step in the biosynthesis of the tetracycline antibiotics tetracycline and oxytetracycline.
History
created 2016
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