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EC 1.3.99.34 Details
EC number
1.3.99.34
Accepted name
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor)
Reaction
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + acceptor = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + reduced acceptor
Other name(s)
AF0464 (gene name)
Systematic name
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate:acceptor oxidoreductase
Comment
A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol 1-phosphate with comparable activity. Geranylgeranyl diphosphate is partially reduced to phytyl diphosphate with 10% of the activity (cf. EC 1.3.1.83, geranylgeranyl diphosphate reductase). Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], the enzyme shows no activity with NADPH. In vitro the enzyme can utilize sodium dithionite as the electron donor.
History
created 2013, deleted 2015
EC Tree
1.3.99.9 created 1976, deleted 2002